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L-glutamic acid-g-poly hydroxyethyl methacrylate nanoparticles: acute and sub-acute toxicity and biodistribution potential in mice.
Bakan, Buket; Oltulu, Fatih; Yildirim, Yeliz; Yavasoglu, Altug; Akgöl, Sinan; Karabay Yavasoglu, Nefise Ülkü.
Afiliación
  • Bakan B; 1Atatürk University Faculty of Science, Department of Molecular Biology and Genetics, Erzurum, Turkey.
  • Oltulu F; 2Ege University Faculty of Science, Department of Biology, Izmir, Turkey.
  • Yildirim Y; 3Ege University Faculty of Medicine, Department of Histology and Embryology, Izmir, Turkey.
  • Yavasoglu A; 4Ege University Faculty of Science, Department of Chemistry, Izmir, Turkey.
  • Akgöl S; 3Ege University Faculty of Medicine, Department of Histology and Embryology, Izmir, Turkey.
  • Karabay Yavasoglu NÜ; 5Ege University Faculty of Science, Department of Biochemistry, Izmir, Turkey.
Arh Hig Rada Toksikol ; 74(3): 207-217, 2023 Sep 01.
Article en En | MEDLINE | ID: mdl-37791671
The aim of this safety study in mice was to determine in vivo toxicity and biodistribution potential of a single and multiple doses of L-glutamic acid-g-p(HEMA) polymeric nanoparticles as a drug delivery system. The single dose did not cause any lethal effect, and its acute oral LD50 was >2.000 mg/kg body weight (bw). Multiple doses (25, 50, or 100 mg/kg bw) given over 28 days resulted in no significant differences in body and relative organ weights compared to control. These results are supported by biochemical and histological findings. Moreover, nanoparticle exposure did not result in statistically significant differences in micronucleus counts in bone marrow cells compared to control. Nanoparticle distribution was time-dependent, and they reached the organs and even bone marrow by hour 6, as established by ex vivo imaging with the IVIS® spectrum imaging system. In conclusion, L-glutamic acid-g-p(HEMA) polymeric nanoparticles appear biocompatible and have a potential use as a drug delivery system.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ácido Glutámico / Nanopartículas Límite: Animals Idioma: En Revista: Arh Hig Rada Toksikol Año: 2023 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Croacia
Texto completo
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Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ácido Glutámico / Nanopartículas Límite: Animals Idioma: En Revista: Arh Hig Rada Toksikol Año: 2023 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Croacia