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Progressive multifocal leukoencephalopathy triggered by COVID-19 in a previously asymptomatic person living with undiagnosed HIV infection.
Pessoa-Gonçalves, Yago Marcos; Farnesi-de-Assunção, Thaís Soares; de Sousa, Marlos Aureliano Dias; Ferreira, Luis Marcos; Matos, Beatriz Sodré; Borges, Anna Victória Bernardes; Oliveira-Scussel, Ana Carolina de Morais; da Silva, Alex Eduardo; Oliveira, Carlo José Freire; da Silva, Marcos Vinicius; Rodrigues, Virmondes.
Afiliación
  • Pessoa-Gonçalves YM; Institute of Natural and Biological Sciences, Department of Microbiology, Immunology and Parasitology, Federal University of Triângulo Mineiro, Uberaba, Brazil.
  • Farnesi-de-Assunção TS; Institute of Natural and Biological Sciences, Department of Microbiology, Immunology and Parasitology, Federal University of Triângulo Mineiro, Uberaba, Brazil.
  • de Sousa MAD; Institute of Health Sciences, Department of Neurology, Federal University of Triângulo Mineiro, Uberaba, Brazil.
  • Ferreira LM; Institute of Health Sciences, Department of Neurology, Federal University of Triângulo Mineiro, Uberaba, Brazil.
  • Matos BS; Institute of Natural and Biological Sciences, Department of Microbiology, Immunology and Parasitology, Federal University of Triângulo Mineiro, Uberaba, Brazil.
  • Borges AVB; Institute of Natural and Biological Sciences, Department of Microbiology, Immunology and Parasitology, Federal University of Triângulo Mineiro, Uberaba, Brazil.
  • Oliveira-Scussel ACM; Institute of Natural and Biological Sciences, Department of Microbiology, Immunology and Parasitology, Federal University of Triângulo Mineiro, Uberaba, Brazil.
  • da Silva AE; Institute of Health Sciences, Department of Neurology, Federal University of Triângulo Mineiro, Uberaba, Brazil.
  • Oliveira CJF; Institute of Natural and Biological Sciences, Department of Microbiology, Immunology and Parasitology, Federal University of Triângulo Mineiro, Uberaba, Brazil. Electronic address: carlo.oliveira@uftm.edu.br.
  • da Silva MV; Institute of Natural and Biological Sciences, Department of Microbiology, Immunology and Parasitology, Federal University of Triângulo Mineiro, Uberaba, Brazil.
  • Rodrigues V; Institute of Natural and Biological Sciences, Department of Microbiology, Immunology and Parasitology, Federal University of Triângulo Mineiro, Uberaba, Brazil.
Int J Infect Dis ; 137: 1-3, 2023 Dec.
Article en En | MEDLINE | ID: mdl-37788739
This report presents the case of a 47-year-old male patient who worked as a mathematics teacher and experienced the sudden onset of disorientation, aphasia, and acalculia during an online class. The current study reveals the first documented case of HIV and progressive multifocal leukoencephalopathy with the detection of SARS-CoV-2 and human polyomavirus 2 (previously known as John Cunningham virus) in the cerebrospinal fluid. Furthermore, serum analysis revealed elevated concentrations of interleukin (IL)-6, IL-17, and IL-8, which are potential factors known to reduce the expression of tight junctions and adhesion molecules in the extracellular matrix, thereby affecting the permeability of the blood-brain barrier. Finally, the study discusses whether SARS-CoV-2 triggers or exacerbates progressive multifocal leukoencephalopathy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones por VIH / Leucoencefalopatía Multifocal Progresiva / Virus JC / COVID-19 Límite: Humans / Male / Middle aged Idioma: En Revista: Int J Infect Dis Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2023 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Canadá
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones por VIH / Leucoencefalopatía Multifocal Progresiva / Virus JC / COVID-19 Límite: Humans / Male / Middle aged Idioma: En Revista: Int J Infect Dis Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2023 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Canadá