Antiepileptic Drugs as Potential Dementia Prophylactics Following Traumatic Brain Injury.
Annu Rev Pharmacol Toxicol
; 64: 577-598, 2024 Jan 23.
Article
en En
| MEDLINE
| ID: mdl-37788493
Seizures and other forms of neurovolatility are emerging as druggable prodromal mechanisms that link traumatic brain injury (TBI) to the progression of later dementias. TBI neurotrauma has both acute and long-term impacts on health, and TBI is a leading risk factor for dementias, including chronic traumatic encephalopathy and Alzheimer's disease. Treatment of TBI already considers acute management of posttraumatic seizures and epilepsy, and impressive efforts have optimized regimens of antiepileptic drugs (AEDs) toward that goal. Here we consider that expanding these management strategies could determine which AED regimens best prevent dementia progression in TBI patients. Challenges with this prophylactic strategy include the potential consequences of prolonged AED treatment and that a large subset of patients are refractory to available AEDs. Addressing these challenges is warranted because the management of seizure activity following TBI offers a rare opportunity to prevent the onset or progression of devastating dementias.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Epilepsia Postraumática
/
Demencia
/
Lesiones Traumáticas del Encéfalo
Tipo de estudio:
Risk_factors_studies
Límite:
Humans
Idioma:
En
Revista:
Annu Rev Pharmacol Toxicol
Año:
2024
Tipo del documento:
Article
Pais de publicación:
Estados Unidos