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The Memorial Sloan Kettering Prognostic Score: Correlation with survival in patients with advanced gastric cancer.
Wan, Mingyu; Ding, Yongfeng; Ma, Xiaolu; Chen, Xiaoyu; Xu, Xin; Mao, Chenyu; Qian, Jiong; Xiao, Cheng; Jiang, Haiping; Zheng, Yulong; Teng, Lisong; Xu, Nong.
Afiliación
  • Wan M; Department of Medical Oncology, The First Affiliated Hospital of Zhejiang University, Hangzhou, China.
  • Ding Y; Department of Medical Oncology, The First Affiliated Hospital of Zhejiang University, Hangzhou, China.
  • Ma X; Department of Medical Oncology, The First Affiliated Hospital of Zhejiang University, Hangzhou, China.
  • Chen X; Department of Medical Oncology, The First Affiliated Hospital of Zhejiang University, Hangzhou, China.
  • Xu X; Department of Medical Oncology, The First Affiliated Hospital of Zhejiang University, Hangzhou, China.
  • Mao C; Department of Medical Oncology, The First Affiliated Hospital of Zhejiang University, Hangzhou, China.
  • Qian J; Department of Medical Oncology, The First Affiliated Hospital of Zhejiang University, Hangzhou, China.
  • Xiao C; Department of Medical Oncology, The First Affiliated Hospital of Zhejiang University, Hangzhou, China.
  • Jiang H; Department of Medical Oncology, The First Affiliated Hospital of Zhejiang University, Hangzhou, China.
  • Zheng Y; Department of Medical Oncology, The First Affiliated Hospital of Zhejiang University, Hangzhou, China.
  • Teng L; Department of Surgical Oncology, The First Affiliated Hospital of Zhejiang University, Hangzhou, China.
  • Xu N; Department of Medical Oncology, The First Affiliated Hospital of Zhejiang University, Hangzhou, China.
Cancer Med ; 12(19): 19656-19666, 2023 10.
Article en En | MEDLINE | ID: mdl-37787070
BACKGROUND: Notwithstanding that the past decade has witnessed unprecedented medical progress, gastric cancer (GC) remains a leading cause of cancer death, highlighting the need for effective prognostic markers. The Memorial Sloan Kettering Prognostic Score (MPS) has been validated as a valuable prognostic tool for patients with metastatic pancreatic adenocarcinoma (mPDAC). This study aimed to assess the prognostic value of the MPS in advanced GC. METHODS: Data from 367 patients were analyzed in the present study. The MPS for each patient was calculated based on the sum of scores based on the neutrophil-to-lymphocyte ratio and serum albumin levels. Multivariate analyses were performed to identify the independent clinicopathological parameters associated with overall survival (OS). Further subgroup analyses based on clinicopathological features were conducted. RESULTS: Patients with MPS 0 (n = 161), MPS 1 (n = 158), and MPS 2 (n = 48) exhibited significantly different OS, with a median survival duration of 20.7 (95%CI: 12.2-29.2), 14.9 (95%CI: 12.5-17.3), and 12.7 (95%CI: 9.3-16.0) months, respectively (p < 0.001). Significant differences in survival were observed among different groups of patients receiving chemotherapy (18.5 months vs. 14.7 months vs. 11.0 months, p = 0.03) or the subgroup receiving chemotherapy plus immunotherapy as first-line treatment (32.6 months vs. 17.7 months vs. 12.7 months, p = 0.02). The MPS was identified as an independent prognostic factor in multivariate analysis. During subgroup analyses, MPS-low (MPS 0) was consistently associated with a better prognosis than MPS-high (MPS 1 or 2). CONCLUSIONS: MPS is a practical, simple, and useful prognostic tool for patients with advanced GC. Further studies are warranted to validate its prognostic value in advanced GC.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / Neoplasias Gástricas / Adenocarcinoma Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Cancer Med Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / Neoplasias Gástricas / Adenocarcinoma Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Cancer Med Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos