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Antioxidant and anti-inflammatory effects of allicin in the kidney of an experimental model of metabolic syndrome.
Arellano Buendia, Abraham Said; Juárez Rojas, Juan Gabriel; García-Arroyo, Fernando; Aparicio Trejo, Omar Emiliano; Sánchez-Muñoz, Fausto; Argüello-García, Raúl; Sánchez-Lozada, Laura Gabriela; Bojalil, Rafael; Osorio-Alonso, Horacio.
Afiliación
  • Arellano Buendia AS; Doctorado en Ciencias Biológicas y de la Salud, Universidad Autónoma Metropolitana, Mexico, Xochimilco, Mexico.
  • Juárez Rojas JG; Fisiopatología Cardio-Renal, Instituto Nacional de Cardiología Ignacio Chávez, Mexico, Tlalpan, México.
  • García-Arroyo F; Endocrinología, Instituto Nacional de Cardiología Ignacio Chávez, Mexico, Tlalpan, México.
  • Aparicio Trejo OE; Fisiopatología Cardio-Renal, Instituto Nacional de Cardiología Ignacio Chávez, Mexico, Tlalpan, México.
  • Sánchez-Muñoz F; Fisiopatología Cardio-Renal, Instituto Nacional de Cardiología Ignacio Chávez, Mexico, Tlalpan, México.
  • Argüello-García R; Inmunología, Instituto Nacional de Cardiología Ignacio Chávez, Mexico, Tlalpan, México.
  • Sánchez-Lozada LG; Genética y Biología Molecular, Centro de Investigación y de Estudios Avanzados del IPN, México, Gustavo A. Madero, México.
  • Bojalil R; Fisiopatología Cardio-Renal, Instituto Nacional de Cardiología Ignacio Chávez, Mexico, Tlalpan, México.
  • Osorio-Alonso H; Atención a la Salud, Universidad Autónoma Metropolitana, Mexico, Xochimilco, México.
PeerJ ; 11: e16132, 2023.
Article en En | MEDLINE | ID: mdl-37786577
Background: Recent studies have suggested that metabolic syndrome (MS) encompasses a group of risk factors for developing chronic kidney disease (CKD). This work aimed to evaluate the antioxidant and anti-inflammatory effects of allicin in the kidney from an experimental model of MS. Methods: Male Wistar rats (220-250 g) were used, and three experimental groups (n = 6) were formed: control (C), metabolic syndrome (MS), and MS treated with allicin (16 mg/Kg/day, gastric gavage) (MS+A). MS was considered when an increase of 20% in at least three parameters (body weight, systolic blood pressure (SBP), fasting blood glucose (FBG), or dyslipidemia) was observed compared to the C group. After the MS diagnosis, allicin was administered for 30 days. Results: Before the treatment with allicin, the MS group showed more significant body weight gain, increased SBP, and FBG, glucose intolerance, and dyslipidemia. In addition, increased markers of kidney damage in urine and blood. Moreover, the MS increased oxidative stress and inflammation in the kidney compared to group C. The allicin treatment prevented further weight gain, reduced SBP, FBG, glucose intolerance, and dyslipidemia. Also, markers of kidney damage in urine and blood were decreased. Further, the oxidative stress and inflammation were decreased in the renal cortex of the MS+A compared to the MS group. Conclusion: Allicin exerts its beneficial effects on the metabolic syndrome by considerably reducing systemic and renal inflammation as well as the oxidative stress. These effects were mediated through the Nrf2 pathway. The results suggest allicin may be a therapeutic alternative for treating kidney injury induced by the metabolic syndrome risk factors.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Intolerancia a la Glucosa / Síndrome Metabólico / Insuficiencia Renal Crónica Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals Idioma: En Revista: PeerJ Año: 2023 Tipo del documento: Article País de afiliación: México Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Intolerancia a la Glucosa / Síndrome Metabólico / Insuficiencia Renal Crónica Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals Idioma: En Revista: PeerJ Año: 2023 Tipo del documento: Article País de afiliación: México Pais de publicación: Estados Unidos