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Somatic evolution of marine transmissible leukemias in the common cockle, Cerastoderma edule.
Bruzos, Alicia L; Santamarina, Martín; García-Souto, Daniel; Díaz, Seila; Rocha, Sara; Zamora, Jorge; Lee, Yunah; Viña-Feás, Alejandro; Quail, Michael A; Otero, Iago; Pequeño-Valtierra, Ana; Temes, Javier; Rodriguez-Castro, Jorge; Aramburu, Leyre; Vidal-Capón, André; Villanueva, Antonio; Costas, Damián; Rodríguez, Rosana; Prieto, Tamara; Tomás, Laura; Alvariño, Pilar; Alonso, Juana; Cao, Asunción; Iglesias, David; Carballal, María J; Amaral, Ana M; Balseiro, Pablo; Calado, Ricardo; El Khalfi, Bouchra; Izagirre, Urtzi; de Montaudouin, Xavier; Pade, Nicolas G; Probert, Ian; Ricardo, Fernando; Ruiz, Pamela; Skazina, Maria; Smolarz, Katarzyna; Pasantes, Juan J; Villalba, Antonio; Ning, Zemin; Ju, Young Seok; Posada, David; Demeulemeester, Jonas; Baez-Ortega, Adrian; Tubio, Jose M C.
Afiliación
  • Bruzos AL; Genomes and Disease, Centre for Research in Molecular Medicine and Chronic Diseases (CiMUS), Universidade de Santiago de Compostela, Santiago de Compostela, Spain.
  • Santamarina M; Department of Zoology, Genetics and Physical Anthropology, Universidade de Santiago de Compostela, Santiago de Compostela, Spain.
  • García-Souto D; Instituto de Investigaciones Sanitarias de Santiago de Compostela (IDIS), Santiago de Compostela, Spain.
  • Díaz S; Genomes and Disease, Centre for Research in Molecular Medicine and Chronic Diseases (CiMUS), Universidade de Santiago de Compostela, Santiago de Compostela, Spain.
  • Rocha S; Department of Zoology, Genetics and Physical Anthropology, Universidade de Santiago de Compostela, Santiago de Compostela, Spain.
  • Zamora J; Instituto de Investigaciones Sanitarias de Santiago de Compostela (IDIS), Santiago de Compostela, Spain.
  • Lee Y; Genomes and Disease, Centre for Research in Molecular Medicine and Chronic Diseases (CiMUS), Universidade de Santiago de Compostela, Santiago de Compostela, Spain.
  • Viña-Feás A; Department of Zoology, Genetics and Physical Anthropology, Universidade de Santiago de Compostela, Santiago de Compostela, Spain.
  • Quail MA; Instituto de Investigaciones Sanitarias de Santiago de Compostela (IDIS), Santiago de Compostela, Spain.
  • Otero I; Wellcome Sanger Institute, Hinxton, UK.
  • Pequeño-Valtierra A; Genomes and Disease, Centre for Research in Molecular Medicine and Chronic Diseases (CiMUS), Universidade de Santiago de Compostela, Santiago de Compostela, Spain.
  • Temes J; ECOMARE, Centre for Environmental and Marine Studies (CESAM) & Department of Biology, University of Aveiro, Aveiro, Portugal.
  • Rodriguez-Castro J; CINBIO, Universidade de Vigo, Vigo, Spain.
  • Aramburu L; Genomes and Disease, Centre for Research in Molecular Medicine and Chronic Diseases (CiMUS), Universidade de Santiago de Compostela, Santiago de Compostela, Spain.
  • Vidal-Capón A; Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea.
  • Villanueva A; Genomes and Disease, Centre for Research in Molecular Medicine and Chronic Diseases (CiMUS), Universidade de Santiago de Compostela, Santiago de Compostela, Spain.
  • Costas D; Instituto de Investigaciones Sanitarias de Santiago de Compostela (IDIS), Santiago de Compostela, Spain.
  • Rodríguez R; Wellcome Sanger Institute, Hinxton, UK.
  • Prieto T; Genomes and Disease, Centre for Research in Molecular Medicine and Chronic Diseases (CiMUS), Universidade de Santiago de Compostela, Santiago de Compostela, Spain.
  • Tomás L; Department of Zoology, Genetics and Physical Anthropology, Universidade de Santiago de Compostela, Santiago de Compostela, Spain.
  • Alvariño P; Instituto de Investigaciones Sanitarias de Santiago de Compostela (IDIS), Santiago de Compostela, Spain.
  • Alonso J; Genomes and Disease, Centre for Research in Molecular Medicine and Chronic Diseases (CiMUS), Universidade de Santiago de Compostela, Santiago de Compostela, Spain.
  • Cao A; Instituto de Investigaciones Sanitarias de Santiago de Compostela (IDIS), Santiago de Compostela, Spain.
  • Iglesias D; Genomes and Disease, Centre for Research in Molecular Medicine and Chronic Diseases (CiMUS), Universidade de Santiago de Compostela, Santiago de Compostela, Spain.
  • Carballal MJ; Instituto de Investigaciones Sanitarias de Santiago de Compostela (IDIS), Santiago de Compostela, Spain.
  • Amaral AM; Genomes and Disease, Centre for Research in Molecular Medicine and Chronic Diseases (CiMUS), Universidade de Santiago de Compostela, Santiago de Compostela, Spain.
  • Balseiro P; Instituto de Investigaciones Sanitarias de Santiago de Compostela (IDIS), Santiago de Compostela, Spain.
  • Calado R; Genomes and Disease, Centre for Research in Molecular Medicine and Chronic Diseases (CiMUS), Universidade de Santiago de Compostela, Santiago de Compostela, Spain.
  • El Khalfi B; Department of Biochemistry, Genetics and Immunology, Universidade de Vigo, Vigo, Spain.
  • Izagirre U; Centro de Investigación Mariña (CIM-ECIMAT), Universidade de Vigo, Vigo, Spain.
  • de Montaudouin X; Centro de Investigación Mariña (CIM-ECIMAT), Universidade de Vigo, Vigo, Spain.
  • Pade NG; Centro de Investigación Mariña (CIM-ECIMAT), Universidade de Vigo, Vigo, Spain.
  • Probert I; CINBIO, Universidade de Vigo, Vigo, Spain.
  • Ricardo F; Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO, Vigo, Spain.
  • Ruiz P; New York Genome Center, New York, NY, USA.
  • Skazina M; CINBIO, Universidade de Vigo, Vigo, Spain.
  • Smolarz K; Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO, Vigo, Spain.
  • Pasantes JJ; CINBIO, Universidade de Vigo, Vigo, Spain.
  • Villalba A; Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO, Vigo, Spain.
  • Ning Z; CINBIO, Universidade de Vigo, Vigo, Spain.
  • Ju YS; Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO, Vigo, Spain.
  • Posada D; Centro de Investigacións Mariñas (CIMA), Consellería do Mar, Xunta de Galicia, Vilanova de Arousa, Spain.
  • Demeulemeester J; Centro de Investigacións Mariñas (CIMA), Consellería do Mar, Xunta de Galicia, Vilanova de Arousa, Spain.
  • Baez-Ortega A; Centro de Investigacións Mariñas (CIMA), Consellería do Mar, Xunta de Galicia, Vilanova de Arousa, Spain.
  • Tubio JMC; Centro de Ciencias do Mar do Algarve (CCMAR), Universidade do Algarve, Faro, Portugal.
Nat Cancer ; 4(11): 1575-1591, 2023 Nov.
Article en En | MEDLINE | ID: mdl-37783803
Transmissible cancers are malignant cell lineages that spread clonally between individuals. Several such cancers, termed bivalve transmissible neoplasia (BTN), induce leukemia-like disease in marine bivalves. This is the case of BTN lineages affecting the common cockle, Cerastoderma edule, which inhabits the Atlantic coasts of Europe and northwest Africa. To investigate the evolution of cockle BTN, we collected 6,854 cockles, diagnosed 390 BTN tumors, generated a reference genome and assessed genomic variation across 61 tumors. Our analyses confirmed the existence of two BTN lineages with hemocytic origins. Mitochondrial variation revealed mitochondrial capture and host co-infection events. Mutational analyses identified lineage-specific signatures, one of which likely reflects DNA alkylation. Cytogenetic and copy number analyses uncovered pervasive genomic instability, with whole-genome duplication, oncogene amplification and alkylation-repair suppression as likely drivers. Satellite DNA distributions suggested ancient clonal origins. Our study illuminates long-term cancer evolution under the sea and reveals tolerance of extreme instability in neoplastic genomes.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Leucemia / Bivalvos / Cardiidae / Neoplasias Límite: Animals / Humans Idioma: En Revista: Nat Cancer Año: 2023 Tipo del documento: Article País de afiliación: España Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Leucemia / Bivalvos / Cardiidae / Neoplasias Límite: Animals / Humans Idioma: En Revista: Nat Cancer Año: 2023 Tipo del documento: Article País de afiliación: España Pais de publicación: Reino Unido