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Invasive Fusarium rhinosinusitis in COVID-19 patients: report of three cases with successful management.
Erami, Mahzad; Aboutalebian, Shima; Hashemi Hezaveh, Seyed Jamal; Matini, Amir Hassan; Momen-Heravi, Mansooreh; Ahsaniarani, Amir Hossein; Arani, Shirin Shafaee; Ganjizadeh, Mohsen; Mirhendi, Hossein.
Afiliación
  • Erami M; Infectious Diseases Research Center, Kashan University of Medical Sciences, Kashan, Iran.
  • Aboutalebian S; Department of Medical Parasitology and Mycology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
  • Hashemi Hezaveh SJ; Mycology Reference Laboratory, Research Core Facilities Laboratory, Isfahan University of Medical Sciences, Isfahan, Iran.
  • Matini AH; Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
  • Momen-Heravi M; Department of Pathology and Histology, School of Medicine, Shahid Beheshti Hospital, Kashan University of Medical Sciences, Kashan, Iran.
  • Ahsaniarani AH; Department of Infectious Disease, School of Medicine, Shahid Beheshti Hospital, Kashan University of Medical Sciences, Kashan, Iran.
  • Arani SS; Department of Otorhinolaryngology, School of Medicine, Matini Hospital, Kashan University of Medical Sciences, Kashan, Iran.
  • Ganjizadeh M; Department of Pathology and Histology, School of Medicine, Shahid Beheshti Hospital, Kashan University of Medical Sciences, Kashan, Iran.
  • Mirhendi H; Infectious Diseases Research Center, Kashan University of Medical Sciences, Kashan, Iran.
Front Cell Infect Microbiol ; 13: 1247491, 2023.
Article en En | MEDLINE | ID: mdl-37780844
Invasive fungal rhinosinusitis (IFRS) is a life-threatening infection that can occur in immunocompromised patients, including those with COVID-19. Although Mucorales and Aspergillus species are the most common causes of IFRS, infections caused by other fungi such as Fusarium are rare. In this report, we present three cases of proven rhinosinusitis fusariosis that occurred during or after COVID-19 infection. The diagnosis was confirmed through microscopy, pathology, and culture, and species identification of the isolates was performed by DNA sequencing the entire ITS1-5.8 rRNA-ITS2 region and translation elongation factor 1-alpha (TEF-1α). Antifungal susceptibility testing was conducted according to CLSI guidelines. The causative agents were identified as Fusarium proliferatum, F. oxysporum + Aspergillus flavus, and F. solani/falciforme. Treatment involved the administration of antifungal medication and endoscopic sinus surgery to remove the affected mucosa, leading to the successful resolution of the infections. However, one patient experienced a recurrence of IFRS caused by A. flavus 15 months later. Early diagnosis and timely medical and surgical treatment are crucial in reducing mortality rates associated with invasive fusariosis. Additionally, the cautious use of corticosteroids in COVID-19 patients is highly recommended.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fusariosis / Fusarium / COVID-19 Tipo de estudio: Guideline / Prognostic_studies / Screening_studies Límite: Humans Idioma: En Revista: Front Cell Infect Microbiol Año: 2023 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fusariosis / Fusarium / COVID-19 Tipo de estudio: Guideline / Prognostic_studies / Screening_studies Límite: Humans Idioma: En Revista: Front Cell Infect Microbiol Año: 2023 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Suiza