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Metabolite profiling and antioxidant capacity of natural Ophiocordyceps gracilis and its cultures using LC-MS/MS-based metabolomics: Comparison with Ophiocordyceps sinensis.
Wang, Yue; Tong, Lingling; Yang, Linhui; Ren, Bo; Guo, Dongsheng.
Afiliación
  • Wang Y; School of Food Science and Pharmaceutical Engineering, Nanjing Normal University, Nanjing, China.
  • Tong L; School of Food Science and Pharmaceutical Engineering, Nanjing Normal University, Nanjing, China.
  • Yang L; School of Food Science and Pharmaceutical Engineering, Nanjing Normal University, Nanjing, China.
  • Ren B; School of Food Science and Pharmaceutical Engineering, Nanjing Normal University, Nanjing, China.
  • Guo D; School of Food Science and Pharmaceutical Engineering, Nanjing Normal University, Nanjing, China.
Phytochem Anal ; 35(2): 308-320, 2024 Mar.
Article en En | MEDLINE | ID: mdl-37779226
INTRODUCTION: Ophiocordyceps gracilis is an entomopathogenic fungus and a precious traditional Chinese medicine with similar medicinal properties to Ophiocordyceps sinensis. However, information on the metabolite profiles of natural O. gracilis and its cultures is lacking, which limits their utilization. OBJECTIVE: The metabolic variations and antioxidant activities of O. gracilis cultures and natural O. gracilis were analyzed to evaluate the nutritional and medicinal value of O. gracilis and its cultures. METHOD: The metabolite profiles of O. gracilis cultures (fruiting bodies and aerial mycelia), natural O. gracilis, and natural O. sinensis were compared by LC-MS/MS coupled with multivariate data analysis. Furthermore, their antioxidant activities were evaluated based on their DPPH• , ABTS•+ , and • OH scavenging abilities. RESULTS: A total of 612 metabolites were identified, and the metabolic compositions of the four Cordyceps samples were similar, with differences observed in the levels of some metabolites. There were 126 differential metabolites between natural O. gracilis and natural O. sinensis, among which fatty acids, carbohydrates, and secondary metabolites are predominant in natural O. gracilis. Furthermore, 116 differential metabolites between O. gracilis cultures and natural Cordyceps were identified, with generally higher levels in O. gracilis cultures than in natural Cordyceps. O. gracilis cultivated fruiting bodies exhibited the strongest antioxidant capacity among Cordyceps samples. Additionally, 46 primary and 24 secondary differential metabolites contribute to antioxidant activities. CONCLUSION: This study provides a reference for the application of natural O. gracilis and its cultures in functional food and medicine from the perspective of metabolites and antioxidant capacity.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cordyceps / Hypocreales Idioma: En Revista: Phytochem Anal Asunto de la revista: BOTANICA / QUIMICA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cordyceps / Hypocreales Idioma: En Revista: Phytochem Anal Asunto de la revista: BOTANICA / QUIMICA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido