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Unravelling the due importance of pseudogenes and their resurrection in plants.
Yadav, Sheel; Kalwan, Gopal; Meena, Shashi; Gill, Sarvajeet Singh; Yadava, Yashwant K; Gaikwad, Kishor; Jain, P K.
Afiliación
  • Yadav S; ICAR-National Institute for Plant Biotechnology, New Delhi, 110012, India; PG School, ICAR-Indian Agricultural Research Institute, New Delhi, 110012, India; Division of Genomic Resources, ICAR-National Bureau of Plant Genetic Resources, New Delhi, 110012, India.
  • Kalwan G; ICAR-National Institute for Plant Biotechnology, New Delhi, 110012, India; PG School, ICAR-Indian Agricultural Research Institute, New Delhi, 110012, India.
  • Meena S; PG School, ICAR-Indian Agricultural Research Institute, New Delhi, 110012, India; Division of Plant Physiology, ICAR-Indian Agricultural Research Institute, New Delhi, 110012, India.
  • Gill SS; Stress Physiology & Molecular Biology Lab, Centre for Biotechnology, Maharshi Dayanand University, Rohtak, 124 001, Haryana, India.
  • Yadava YK; ICAR-National Institute for Plant Biotechnology, New Delhi, 110012, India.
  • Gaikwad K; ICAR-National Institute for Plant Biotechnology, New Delhi, 110012, India.
  • Jain PK; ICAR-National Institute for Plant Biotechnology, New Delhi, 110012, India. Electronic address: Pradeep.Jain@icar.gov.in.
Plant Physiol Biochem ; 203: 108062, 2023 Oct.
Article en En | MEDLINE | ID: mdl-37778114
The complexities of a genome are underpinned to the vast expanses of the intergenic region, which constitutes ∼97-98% of the genome. This region is essentially composed of what is colloquially referred to as the "junk DNA" and is composed of various elements like transposons, repeats, pseudogenes, etc. The latter have long been considered as dead elements merely contributing to transcriptional noise in the genome. Many studies now describe the previously unknown regulatory functions of these genes. Recent advances in the Next-generation sequencing (NGS) technologies have allowed unprecedented access to these regions. With the availability of whole genome sequences of more than 788 different plant species in past 20 years, genome annotation has become feasible like never before. Different bioinformatic pipelines are available for the identification of pseudogenes. However, still little is known about their biological functions. The functional validation of these genes remains challenging and research in this area is still in infancy, particularly in plants. CRISPR/Cas-based genome editing could provide solutions to understand the biological roles of these genes by allowing creation of precise edits within these genes. The possibility of pseudogene reactivation or resurrection as has been demonstrated in a few studies might open new avenues of genetic manipulation to yield a desirable phenotype. This review aims at comprehensively summarizing the progress made with regards to the identification of pseudogenes and understanding their biological functions in plants.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Seudogenes / Genoma Idioma: En Revista: Plant Physiol Biochem Asunto de la revista: BIOQUIMICA / BOTANICA Año: 2023 Tipo del documento: Article País de afiliación: India Pais de publicación: Francia
Texto completo
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Imprimir
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Seudogenes / Genoma Idioma: En Revista: Plant Physiol Biochem Asunto de la revista: BIOQUIMICA / BOTANICA Año: 2023 Tipo del documento: Article País de afiliación: India Pais de publicación: Francia