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Piloting a forced-choice task to elicit treatment preferences in geographic atrophy.
Enoch, Jamie; Ghulakhszian, Arevik; Sekhon, Mandeep; Crabb, David P; Taylor, Deanna J; Dinah, Christiana.
Afiliación
  • Enoch J; Department of Optometry and Visual Sciences, City, University of London, London, UK.
  • Ghulakhszian A; Ophthalmology Department, London North West University Healthcare NHS Trust, Central Middlesex Hospital, London, UK.
  • Sekhon M; Centre for Applied Health and Social Care Research, Kingston and St George's, University of London, London, UK.
  • Crabb DP; Department of Optometry and Visual Sciences, City, University of London, London, UK.
  • Taylor DJ; Department of Optometry and Visual Sciences, City, University of London, London, UK.
  • Dinah C; Ophthalmology Department, London North West University Healthcare NHS Trust, Central Middlesex Hospital, London, UK. christiana.dinah@nhs.net.
BMC Res Notes ; 16(1): 244, 2023 Sep 30.
Article en En | MEDLINE | ID: mdl-37777762
OBJECTIVE: Geographic Atrophy (GA) is the advanced form of the non-neovascular ('dry') type of age-related macular degeneration (AMD) and responsible for one-quarter of legal blindness in the UK. New therapies delivered by intravitreal injection are in late-stage development, and two such therapies (pegcetacoplan (Syfovre) and avacincaptad pegol (Izervay)) have now been approved for clinical use by the US Food and Drug Administration. These therapies slow down, but do not stop or reverse, progression of GA and they may also increase the risk of developing the neovascular ('wet') type of AMD. Within a larger study exploring the acceptability of these new treatments to people living with GA, we developed a forced-choice exercise to evaluate how participants weigh up benefits and drawbacks of different treatment regimens. This research note reports quantitative and qualitative findings from this exercise. RESULTS: Twenty-eight participants took part in this exercise. The exercise demonstrated that participants were generally, although not unanimously, in favour of less frequent treatment for GA that was slightly less efficacious in terms of preserving visual function but presented a lower risk of developing wet AMD. Even among a small sample, the exercise demonstrated the highly personal and idiosyncratic decision-making processes influencing participants' choices of preferred hypothetical GA treatment.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Atrofia Geográfica / Degeneración Macular Tipo de estudio: Prognostic_studies / Qualitative_research Aspecto: Patient_preference Límite: Humans Idioma: En Revista: BMC Res Notes Año: 2023 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Atrofia Geográfica / Degeneración Macular Tipo de estudio: Prognostic_studies / Qualitative_research Aspecto: Patient_preference Límite: Humans Idioma: En Revista: BMC Res Notes Año: 2023 Tipo del documento: Article Pais de publicación: Reino Unido