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When practice does not make a perfect - paradoxical learning curve in schizophrenia and bipolar disorder revealed by different serial reaction time task variants.
Chrobak, Adrian Andrzej; Siuda-Krzywicka, Katarzyna; Soltys, Zbigniew; Bielak, Sylwia; Nowaczek, Dominik; Zyrkowska, Aleksandra; Fafrowicz, Magdalena; Marek, Tadeusz; Pecherzewska, Ewa; Kuzdzal, Jan; Starowicz-Filip, Anna; Gorostowicz, Aleksandra; Dudek, Dominika; Siwek, Marcin.
Afiliación
  • Chrobak AA; Department of Adult Psychiatry, Jagiellonian University Medical College, Kraków, Poland.
  • Siuda-Krzywicka K; Faculté de Médecine, Sorbonne Université, Paris, France.
  • Soltys Z; Laboratory of Experimental Neuropathology, Institute of Zoology and Biomedical Research, Jagiellonian University, Kraków, Poland.
  • Bielak S; Department of Adult, Child and Adolescent Psychiatry, University Hospital in Cracow, Kraków, Poland.
  • Nowaczek D; J. Dietl Specialist Hospital, Kraków, Poland.
  • Zyrkowska A; Department of Cognitive Neuroscience and Neuroergonomics, Institute of Applied Psychology, Jagiellonian University, Kraków, Poland.
  • Fafrowicz M; Doctoral School in the Social Sciences, Jagiellonian University, Kraków, Poland.
  • Marek T; Department of Cognitive Neuroscience and Neuroergonomics, Institute of Applied Psychology, Jagiellonian University, Kraków, Poland.
  • Pecherzewska E; Faculty of Psychology, SWPS University of Social Sciences and Humanities, Katowice, Poland.
  • Kuzdzal J; Malopolska Centre of Biotechnology, Kraków, Poland.
  • Starowicz-Filip A; Malopolska Centre of Biotechnology, Kraków, Poland.
  • Gorostowicz A; Medical Psychology Department, Jagiellonian University Medical College, Kraków, Poland.
  • Dudek D; Department of Adult Psychiatry, Jagiellonian University Medical College, Kraków, Poland.
  • Siwek M; Department of Adult Psychiatry, Jagiellonian University Medical College, Kraków, Poland.
Front Psychiatry ; 14: 1238473, 2023.
Article en En | MEDLINE | ID: mdl-37766926
Introduction: Our previous studies identified a paradoxical implicit motor learning curve in schizophrenia (SZ) and bipolar disorder (BD) patients. This study aimed to verify whether those previously observed deficits may be captured by a new version of the ambidextrous serial reaction time task (SRTT), prepared for use in the MRI. Methods: This study involved 186 participants. A total of 97 participants (33 BD, 33 SZ, and 31 healthy controls, HCs) completed the original, unlimited time response variant of SRTT. A total of 90 individuals (30 BD, 30 SZ, and 30 HCs) underwent a newer, limited response time version of this procedure. Results: There was no significant difference in terms of implicit motor learning indices between both limited and unlimited response time SRTT. Compared to HCs, SZ, and BD patients presented decreased indices of implicit motor learning. Both clinical groups showed a paradoxical learning pattern that differed significantly from the HCs. Moreover, in the SZ group, the pattern depended on the hand performing SRTT. Discussion: The limited response time SRTT variant allowed us to replicate the findings of disrupted implicit motor learning in SZ and BD. The use of this paradigm in further neuroimaging studies may help to determine the neuronal underpinnings of this cognitive dysfunction in the abovementioned clinical groups.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Front Psychiatry Año: 2023 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Suiza
Texto completo
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Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Front Psychiatry Año: 2023 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Suiza