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Alkylresorcinols as New Modulators of the Metabolic Activity of the Gut Microbiota.
Zabolotneva, Anastasia A; Gaponov, Andrei M; Roumiantsev, Sergey A; Vasiliev, Ilya Yu; Grigoryeva, Tatiana V; Kit, Oleg I; Zlatnik, Elena Yu; Maksimov, Aleksey Yu; Goncharova, Anna S; Novikova, Inna A; Appolonova, Svetlana A; Markin, Pavel A; Shestopalov, Aleksandr V.
Afiliación
  • Zabolotneva AA; Department of Biochemistry and Molecular Biology, Faculty of Medicine, N. I. Pirogov Russian National Research Medical University, 1 Ostrovitianov Str., Moscow 117997, Russia.
  • Gaponov AM; Russian National Medical Research Center for Endocrinology, 11 Dm. Ulyanova Str., Moscow 117036, Russia.
  • Roumiantsev SA; Center for Digital and Translational Biomedicine «Center for Molecular Health¼, 32 Nakhimovskiy prospekt, Moscow 117218, Russia.
  • Vasiliev IY; Department of Biochemistry and Molecular Biology, Faculty of Medicine, N. I. Pirogov Russian National Research Medical University, 1 Ostrovitianov Str., Moscow 117997, Russia.
  • Grigoryeva TV; Russian National Medical Research Center for Endocrinology, 11 Dm. Ulyanova Str., Moscow 117036, Russia.
  • Kit OI; Institute of Fundamental Medicine and Biology, Kazan Federal University, 18 Kremlyovskaya Street, Kazan 420008, Russia.
  • Zlatnik EY; Institute of Fundamental Medicine and Biology, Kazan Federal University, 18 Kremlyovskaya Street, Kazan 420008, Russia.
  • Maksimov AY; National Medical Research Centre for Oncology, 14 Line, 63, Rostov-on-Don 344019, Russia.
  • Goncharova AS; National Medical Research Centre for Oncology, 14 Line, 63, Rostov-on-Don 344019, Russia.
  • Novikova IA; National Medical Research Centre for Oncology, 14 Line, 63, Rostov-on-Don 344019, Russia.
  • Appolonova SA; National Medical Research Centre for Oncology, 14 Line, 63, Rostov-on-Don 344019, Russia.
  • Markin PA; National Medical Research Centre for Oncology, 14 Line, 63, Rostov-on-Don 344019, Russia.
  • Shestopalov AV; Laboratory of Pharmacokinetics and Metabolomic Analysis, Institute of Translational Medicine and Biotechnology, Sechenov First Moscow State Medical University, 2-4 Bolshaya Pirogovskaya St., Moscow 119991, Russia.
Int J Mol Sci ; 24(18)2023 Sep 18.
Article en En | MEDLINE | ID: mdl-37762509
Alkylresorcinols (ARs) are polyphenolic compounds with a wide spectrum of biological activities and are potentially involved in the regulation of host metabolism. The present study aims to establish whether ARs can be produced by the human gut microbiota and to evaluate alterations in content in stool samples as well as metabolic activity of the gut microbiota of C57BL, db/db, and LDLR (-/-) mice according to diet specifications and olivetol (5-n-pentylresorcinol) supplementation to estimate the regulatory potential of ARs. Gas chromatography with mass spectrometric detection was used to quantitatively analyse AR levels in mouse stool samples; faecal microbiota transplantation (FMT) from human donors to germ-free mice was performed to determine whether the intestinal microbiota could produce AR molecules; metagenome sequencing analysis of the mouse gut microbiota followed by reconstruction of its metabolic activity was performed to investigate olivetol's regulatory potential. A significant increase in the amounts of individual members of AR homologues in stool samples was revealed 14 days after FMT. Supplementation of 5-n-Pentylresorcinol to a regular diet influences the amounts of several ARs in the stool of C57BL/6 and LDLR (-/-) but not db/db mice, and caused a significant change in the predicted metabolic activity of the intestinal microbiota of C57BL/6 and LDLR (-/-) but not db/db mice. For the first time, we have shown that several ARs can be produced by the intestinal microbiota. Taking into account the dependence of AR levels in the gut on olivetol supplementation and microbiota metabolic activity, AR can be assumed to be potential quorum-sensing molecules, which also influence gut microbiota composition and host metabolism.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Int J Mol Sci Año: 2023 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Int J Mol Sci Año: 2023 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Suiza