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Association of PCSK1 and PPARG1 Allelic Variants with Obesity and Metabolic Syndrome in Mexican Adults.
Velazquez-Roman, Jorge; Angulo-Zamudio, Uriel A; Leon-Sicairos, Nidia; Flores-Villaseñor, Hector; Benitez-Baez, Miriam; Espinoza-Salomón, Ana; Karam-León, Alejandra; Villamil-Ramírez, Hugo; Canizales-Quinteros, Samuel; Macías-Kauffer, Luis; Monroy-Higuera, Jose; Acosta-Smith, Erika; Canizalez-Roman, Adrian.
Afiliación
  • Velazquez-Roman J; School of Medicine, Autonomous University of Sinaloa, Culiacan Sinaloa 80019, Mexico.
  • Angulo-Zamudio UA; School of Medicine, Autonomous University of Sinaloa, Culiacan Sinaloa 80019, Mexico.
  • Leon-Sicairos N; School of Medicine, Autonomous University of Sinaloa, Culiacan Sinaloa 80019, Mexico.
  • Flores-Villaseñor H; Pediatric Hospital of Sinaloa, Constitución 530, Jorge Almada, Culiacan Sinaloa 80200, Mexico.
  • Benitez-Baez M; School of Medicine, Autonomous University of Sinaloa, Culiacan Sinaloa 80019, Mexico.
  • Espinoza-Salomón A; The Sinaloa State Public Health Laboratory, Secretariat of Health, Culiacan Sinaloa 80020, Mexico.
  • Karam-León A; Programa de Doctorado, Posgrado Integral en Biotecnología, FCQB, UAS, Culiacan Sinaloa 80013, Mexico.
  • Villamil-Ramírez H; School of Medicine, Autonomous University of Sinaloa, Culiacan Sinaloa 80019, Mexico.
  • Canizales-Quinteros S; Programa de Doctorado, Posgrado Integral en Biotecnología, FCQB, UAS, Culiacan Sinaloa 80013, Mexico.
  • Macías-Kauffer L; Unidad de Genómica de Poblaciones Aplicada a la Salud, Facultad de Química, UNAM/INMEGEN, Mexico City 04510, Mexico.
  • Monroy-Higuera J; Unidad de Genómica de Poblaciones Aplicada a la Salud, Facultad de Química, UNAM/INMEGEN, Mexico City 04510, Mexico.
  • Acosta-Smith E; Unidad de Genómica de Poblaciones Aplicada a la Salud, Facultad de Química, UNAM/INMEGEN, Mexico City 04510, Mexico.
  • Canizalez-Roman A; Programa de Doctorado, Posgrado Integral en Biotecnología, FCQB, UAS, Culiacan Sinaloa 80013, Mexico.
Genes (Basel) ; 14(9)2023 09 08.
Article en En | MEDLINE | ID: mdl-37761915
Metabolic diseases, including obesity, diabetes, and metabolic syndrome, are among the most important public health challenges worldwide. Metabolic diseases are classified as multifactorial diseases in which genetic variants such as single-nucleotide polymorphisms (SNPs) may play an important role. The present study aimed to identify associations linking allelic variants of the PCSK1, TMEM18, GPX5, ZPR1, ZBTB16, and PPARG1 genes with anthropometric and biochemical traits and metabolic diseases (obesity or metabolic syndrome) in an adult population from northwestern Mexico. METHODS: Blood samples were collected from 523 subjects, including 247 with normal weight, 276 with obesity, and 147 with metabolic syndrome. Anthropometric and biochemical characteristics were recorded, and single-nucleotide polymorphisms (SNPs) were genotyped by real-time PCR. RESULTS: PCSK1 was significantly (p < 0.05) associated with BMI, weight, and waist-to-hip ratio; TMEM18 was significantly associated with systolic blood pressure and triglyceride levels; GPX5 was significantly associated with HDL cholesterol levels. In addition, PCSK1 was associated with obesity (p = 1.0 × 10-4) and metabolic syndrome (p = 3.0 × 10-3), whereas PPARG1 was associated with obesity (p = 0.044). CONCLUSIONS: The associations found in this study, mainly between allelic variants of PCSK1 and metabolic traits, obesity, and metabolic syndrome, may represent a risk for developing metabolic diseases in adult subjects from northwestern Mexico.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Síndrome Metabólico Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Adult / Humans País/Región como asunto: Mexico Idioma: En Revista: Genes (Basel) Año: 2023 Tipo del documento: Article País de afiliación: México Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Síndrome Metabólico Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Adult / Humans País/Región como asunto: Mexico Idioma: En Revista: Genes (Basel) Año: 2023 Tipo del documento: Article País de afiliación: México Pais de publicación: Suiza