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Cardiac Dose Predicts the Response to Concurrent Chemoradiotherapy in Esophageal Squamous Cell Carcinoma.
Ho, Yu-Chieh; Lai, Yuan-Chun; Lin, Hsuan-Yu; Ko, Ming-Hui; Wang, Sheng-Hung; Yang, Shan-Jun; Chou, Tsai-Wei; Hung, Li-Chung; Huang, Chia-Chun; Chang, Tung-Hao; Lin, Jhen-Bin; Lin, Jin-Ching.
Afiliación
  • Ho YC; Department of Radiation Oncology, Changhua Christian Hospital, Changhua 500, Taiwan.
  • Lai YC; Division of Medical Physics, Department of Radiation Oncology, Changhua Christian Hospital, Changhua 500, Taiwan.
  • Lin HY; Department of Medical Imaging Radiological Science, Central Taiwan University of Science and Technology, Taichung 406, Taiwan.
  • Ko MH; Division of Haematology/Oncology, Department of Internal Medicine, Changhua Christian Hospital, Changhua 500, Taiwan.
  • Wang SH; Division of Medical Physics, Department of Radiation Oncology, Changhua Christian Hospital, Changhua 500, Taiwan.
  • Yang SJ; Department of Radiation Oncology, Lukang Christian Hospital, Changhua Christian Medical Foundation, Lukang 505, Taiwan.
  • Chou TW; Department of Radiation Oncology, Changhua Christian Hospital, Changhua 500, Taiwan.
  • Hung LC; Department of Radiation Oncology, Changhua Christian Hospital, Changhua 500, Taiwan.
  • Huang CC; Department of Radiation Oncology, Changhua Christian Hospital, Changhua 500, Taiwan.
  • Chang TH; Department of Radiation Oncology, Changhua Christian Hospital, Changhua 500, Taiwan.
  • Lin JB; Department of Radiation Oncology, Changhua Christian Hospital, Changhua 500, Taiwan.
  • Lin JC; Department of Medical Imaging Radiological Science, Central Taiwan University of Science and Technology, Taichung 406, Taiwan.
Cancers (Basel) ; 15(18)2023 Sep 15.
Article en En | MEDLINE | ID: mdl-37760549
Definitive concurrent chemoradiation (CCRT) is the standard treatment for cervical esophageal cancer and non-surgical candidates. Initial treatment response affects survival; however, few validated markers are available for prediction. This study evaluated the clinical variables and chemoradiation parameters associated with treatment response. Between May 2010 and April 2016, 86 completed CCRT patients' clinical, dosimetric, and laboratory data at baseline and during treatment were collected. Cox regression analysis assessed the risk factors for overall survival (OS). A receiver operating characteristic curve with Youden's index was chosen to obtain the optimal cut-off value of each parameter. Treatment response was defined per Response Evaluation Criteria in Solid Tumors v.1.1 at the first post-CCRT computed tomography scan. Responders had complete and partial responses; non-responders had stable and progressive diseases. Logistic regression (LR) was used to evaluate the variables associated with responders. The Cox regression model confirmed the presence of responders (n = 50) vs. non-responders (n = 36) with a significant difference in OS. In multivariate LR, cardiac dose-volume received ≥10 Gy; the baseline hemoglobin level, highest neutrophil to lymphocyte ratio during CCRT, and cumulative cisplatin dose were significantly associated with the responders. The initial clinical treatment response significantly determines disease outcome. Cardiac irradiation may affect the treatment response.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies / Risk_factors_studies Idioma: En Revista: Cancers (Basel) Año: 2023 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies / Risk_factors_studies Idioma: En Revista: Cancers (Basel) Año: 2023 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Suiza