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Genetic and clinical variables act synergistically to impact neurodevelopmental outcomes in children with single ventricle heart disease.
Miller, Thomas A; Hernandez, Edgar J; Gaynor, J William; Russell, Mark W; Newburger, Jane W; Chung, Wendy; Goldmuntz, Elizabeth; Cnota, James F; Zyblewski, Sinai C; Mahle, William T; Zak, Victor; Ravishankar, Chitra; Kaltman, Jonathan R; McCrindle, Brian W; Clarke, Shanelle; Votava-Smith, Jodie K; Graham, Eric M; Seed, Mike; Rudd, Nancy; Bernstein, Daniel; Lee, Teresa M; Yandell, Mark; Tristani-Firouzi, Martin.
Afiliación
  • Miller TA; Department of Pediatrics, Maine Medical Center, Portland, ME, USA. Thomas.A.Miller@mainehealth.org.
  • Hernandez EJ; Department of Human Genetics and Utah Center for Genetic Discovery, University of Utah, Salt Lake City, UT, USA.
  • Gaynor JW; Department of Surgery, Children's Hospital of Philadelphia, and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Russell MW; Department of Pediatrics, University of Michigan, Ann Arbor, MI, USA.
  • Newburger JW; Department of Cardiology, Boston Children's Hospital, Department of Pediatrics, Harvard Medical School, Boston, MA, USA.
  • Chung W; Departments of Pediatrics and Medicine, Columbia University, New York, NY, USA.
  • Goldmuntz E; Division of Cardiology, Children's Hospital of Philadelphia, Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Cnota JF; Heart Institute, Cincinnati Children's Hospital, Cincinnati, OH, USA.
  • Zyblewski SC; Department of Pediatrics, Medical University of South Carolina, Charleston, SC, USA.
  • Mahle WT; Children's Healthcare of Atlanta, Atlanta, GA, USA.
  • Zak V; Healthcore, Watertown, MA, USA.
  • Ravishankar C; Division of Cardiology, Children's Hospital of Philadelphia, Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Kaltman JR; Division of Cardiology, Children's National Hospital, Washington, DC, USA.
  • McCrindle BW; Labatt Family Heart Centre, The Hospital for Sick Children, Department of Pediatrics, University of Toronto, Toronto, ON, Canada.
  • Clarke S; Department of Pediatrics Emory University School of Medicine, Atlanta, GA, USA.
  • Votava-Smith JK; Department of Pediatrics, Children's Hospital Los Angeles, Los Angeles, CA, USA.
  • Graham EM; Department of Pediatrics, Medical University of South Carolina, Charleston, SC, USA.
  • Seed M; Labatt Family Heart Centre, The Hospital for Sick Children, Department of Pediatrics, University of Toronto, Toronto, ON, Canada.
  • Rudd N; Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, USA.
  • Bernstein D; Stanford University School of Medicine, Stanford, CA, USA.
  • Lee TM; Departments of Pediatrics and Medicine, Columbia University, New York, NY, USA.
  • Yandell M; Department of Human Genetics and Utah Center for Genetic Discovery, University of Utah, Salt Lake City, UT, USA. myandell@genetics.utah.edu.
  • Tristani-Firouzi M; Department of Pediatrics, University of Utah, Salt Lake City, UT, USA. Martin.Tristani@utah.edu.
Commun Med (Lond) ; 3(1): 127, 2023 Sep 27.
Article en En | MEDLINE | ID: mdl-37758840
Single ventricle congenital heart disease is a birth defect. In these children, the heart has only one effective blood-pumping chamber instead of two. Surgery can reroute the blood to use only one chamber, but multiple risk factors influence how well a child develops afterwards. Studying these risk factors can be challenging because they are interconnected, i.e. children with a genetic birth defect may be more likely to have a lower birthweight, and hence more likely to spend longer in hospital after surgery. Here, we used a statistical approach not commonly applied to study congenital heart disease and describe that whether a genetic variant (a small difference in a child's DNA) is important for how a child with single ventricle heart disease develops and grows after surgery depends on the presence of other risk factors.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies / Risk_factors_studies Idioma: En Revista: Commun Med (Lond) Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies / Risk_factors_studies Idioma: En Revista: Commun Med (Lond) Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido