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3D Filaments Based on Polyhydroxy Butyrate-Micronized Bacterial Cellulose for Tissue Engineering Applications.
Celestino, Matheus F; Lima, Lais R; Fontes, Marina; Batista, Igor T S; Mulinari, Daniella R; Dametto, Alessandra; Rattes, Raphael A; Amaral, André C; Assunção, Rosana M N; Ribeiro, Clovis A; Castro, Guillermo R; Barud, Hernane S.
Afiliación
  • Celestino MF; Biopolymers and Biomaterials Group, Postgraduate Program in Biotechnology, University of Araraquara (UNIARA), Araraquara 14801-320, SP, Brazil.
  • Lima LR; Institute of Chemistry, University of São Paulo (USP), São Carlos 13566-590, SP, Brazil.
  • Fontes M; Biopolymers and Biomaterials Group, Postgraduate Program in Biotechnology, University of Araraquara (UNIARA), Araraquara 14801-320, SP, Brazil.
  • Batista ITS; Biosmart Nanotechnology LTDA, Araraquara 14808-162, SP, Brazil.
  • Mulinari DR; Biopolymers and Biomaterials Group, Postgraduate Program in Biotechnology, University of Araraquara (UNIARA), Araraquara 14801-320, SP, Brazil.
  • Dametto A; Department of Mechanics and Energy, State University of Rio de Janeiro (UEJR), Rio de Janeiro 20550-900, RJ, Brazil.
  • Rattes RA; Biosmart Nanotechnology LTDA, Araraquara 14808-162, SP, Brazil.
  • Amaral AC; Biopolymers and Biomaterials Group, Postgraduate Program in Biotechnology, University of Araraquara (UNIARA), Araraquara 14801-320, SP, Brazil.
  • Assunção RMN; Biopolymers and Biomaterials Group, Postgraduate Program in Biotechnology, University of Araraquara (UNIARA), Araraquara 14801-320, SP, Brazil.
  • Ribeiro CA; Faculty of Integrated Sciences of Pontal (FACIP), Federal University of Uberlandia (UFU), Pontal Campus, Ituiutaba 38304-402, MG, Brazil.
  • Castro GR; Institute of Chemistry, São Paulo State University (UNESP), Araraquara 14800-900, SP, Brazil.
  • Barud HS; Nanomedicine Research Unit (Nanomed), Center for Natural and Human Sciences, Federal University of ABC (UFABC), Santo André 09210-580, SP, Brazil.
J Funct Biomater ; 14(9)2023 Sep 09.
Article en En | MEDLINE | ID: mdl-37754878
In this work, scaffolds based on poly(hydroxybutyrate) (PHB) and micronized bacterial cellulose (BC) were produced through 3D printing. Filaments for the printing were obtained by varying the percentage of micronized BC (0.25, 0.50, 1.00, and 2.00%) inserted in relation to the PHB matrix. Despite the varying concentrations of BC, the biocomposite filaments predominantly contained PHB functional groups, as Fourier transform infrared spectroscopy (FTIR) demonstrated. Thermogravimetric analyses (i.e., TG and DTG) of the filaments showed that the peak temperature (Tpeak) of PHB degradation decreased as the concentration of BC increased, with the lowest being 248 °C, referring to the biocomposite filament PHB/2.0% BC, which has the highest concentration of BC. Although there was a variation in the thermal behavior of the filaments, it was not significant enough to make printing impossible, considering that the PHB melting temperature was 170 °C. Biological assays indicated the non-cytotoxicity of scaffolds and the provision of cell anchorage sites. The results obtained in this research open up new paths for the application of this innovation in tissue engineering.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Funct Biomater Año: 2023 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Funct Biomater Año: 2023 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Suiza