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Case Report: A Presentation of Early-Onset Immune-Mediated Bullous Pemphigoid in a Patient with Urothelial Cancer.
Sabaté Ortega, Josep; Fort Culillas, Roser; Escoda Garcia, Marina; Vásquez-Dongo, Carmen Amalia; Sala González, Núria.
Afiliación
  • Sabaté Ortega J; Oncology Department, Catalan Institute of Oncology, Hospital Universitari Doctor Josep Trueta, 17007 Girona, Spain.
  • Fort Culillas R; Oncology Department, Catalan Institute of Oncology, Hospital Universitari Doctor Josep Trueta, 17007 Girona, Spain.
  • Escoda Garcia M; Dermatology Department, Hospital Universitari Doctor Josep Trueta, 17007 Girona, Spain.
  • Vásquez-Dongo CA; Pathology Department, Hospital Universitari Doctor Josep Trueta, 17007 Girona, Spain.
  • Sala González N; Oncology Department, Catalan Institute of Oncology, Hospital Universitari Doctor Josep Trueta, 17007 Girona, Spain.
Curr Oncol ; 30(9): 7802-7809, 2023 08 23.
Article en En | MEDLINE | ID: mdl-37754481
Cutaneous immune-related adverse events (cirAEs) are the most common side effects of immune checkpoint inhibitor (ICI) therapy (30-50% for all grades). The vast majority of them are low or mild and can be treated without ICI interruption. Autoimmune blistering disorders, such as immune-mediated bullous pemphigoid (IBP), are rare (<1%) but potentially serious conditions that must be early detected. The onset generally occurs within the first months of the treatment, and it appears to be more common with antiprogrammed death-1 or antiprogrammed ligand 1 (anti-PD1/PDL1) than with anticytotoxic T-lymphocyte-associated protein 4 (anti-CTLA4). We present a case of a three-day severe IBP onset after receiving the first cycle of atezolizumab. This exceptional early presentation could suggest the presence of some predisposing condition and demonstrates the need to better understand predictive toxicity-related biomarkers in candidate patients for immunotherapy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Vejiga Urinaria / Carcinoma de Células Transicionales / Penfigoide Ampolloso Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Curr Oncol Año: 2023 Tipo del documento: Article País de afiliación: España Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Vejiga Urinaria / Carcinoma de Células Transicionales / Penfigoide Ampolloso Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Curr Oncol Año: 2023 Tipo del documento: Article País de afiliación: España Pais de publicación: Suiza