Deferasirox Derivatives: Ligands for the Lanthanide Series.

Mangel, Daniel N; Juarez, Gabriel J; Carpenter, Stephanie H; Steinbrueck, Axel; Lynch, Vincent M; Yang, Jian; Sedgwick, Adam C; Tondreau, Aaron; Sessler, Jonathan L

Mangel, Daniel N; Juarez, Gabriel J; Carpenter, Stephanie H; Steinbrueck, Axel; Lynch, Vincent M; Yang, Jian; Sedgwick, Adam C; Tondreau, Aaron; Sessler, Jonathan L.

Afiliación

Mangel DN; Department of Chemistry, The University of Texas at Austin, 105 East 24th Street-A5300, Austin, Texas 78712-1224, United States.
Juarez GJ; Department of Chemistry, The University of Texas at Austin, 105 East 24th Street-A5300, Austin, Texas 78712-1224, United States.
Carpenter SH; Los Alamos National Laboratory, Los Alamos, New Mexico 87545, United States.
Steinbrueck A; Department of Chemistry, The University of Texas at Austin, 105 East 24th Street-A5300, Austin, Texas 78712-1224, United States.
Lynch VM; Department of Chemistry, The University of Texas at Austin, 105 East 24th Street-A5300, Austin, Texas 78712-1224, United States.
Yang J; Department of Chemistry, The University of Texas at Austin, 105 East 24th Street-A5300, Austin, Texas 78712-1224, United States.
Sedgwick AC; Department of Chemistry, University of Oxford, Mansfield Road, Oxford OX1 3TA, U.K.
Tondreau A; Los Alamos National Laboratory, Los Alamos, New Mexico 87545, United States.
Sessler JL; Department of Chemistry, The University of Texas at Austin, 105 East 24th Street-A5300, Austin, Texas 78712-1224, United States.

J Am Chem Soc ; 145(40): 22206-22212, 2023 Oct 11.

Article en En | MEDLINE | ID: mdl-37751361

RESUMEN

Deferasirox is an FDA-approved iron chelator used in the treatment of iron toxicity. In this work, we report the use of several deferasirox derivatives as lanthanide chelators. Solid-state structural studies of three representative trivalent lanthanide cations, La(III), Eu(III), and Lu(III), revealed the formation of 2:2 complexes in the solid state. A 1:1 stoichiometry dominates in DMSO solution, with Ka values of 472 ± 14, 477 ± 11, and 496 ± 15 M-1 being obtained in the case of these three cations, respectively. Under the conditions of competitive precipitation in the presence of triethylamine, high selectivity (up to 80%) for lutetium(III) was observed in competition with La(III), Ce(III), and Eu(III). Theoretical calculations provided support for the observed selective crystallization.

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Am Chem Soc Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos

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