Comparison of sperm carnitine profiles of normospermic, oligospermic and azospermic individuals.
Eur Rev Med Pharmacol Sci
; 27(17): 8154-8162, 2023 Sep.
Article
en En
| MEDLINE
| ID: mdl-37750643
OBJECTIVE: The World Health Organization recognizes infertility as a public health issue. An estimated 48.5 million couples worldwide grapple with infertility. Infertility and spermatogenesis dysfunction arise from diverse genetic factors, including single-gene mutations and chromosomal abnormalities. Current research continues to explore other potential causes of infertility, leveraging both proteomic and metabolomic analyses. The primary aim of this study is to underscore the significance of investigating male infertility from a metabolomic perspective. PATIENTS AND METHODS: This study aimed to identify new markers for diagnosing and treating male infertility by examining the carnitine profiles in seminal fluids of individuals diagnosed with the normospermic group, oligospermic group, and azospermic group, employing the LC/MS-MS method. RESULTS: The first three L-carnitines C2 (Acetylcarnitine), C8:1 (Octenoylcarnitine), and C16:1 (Palmitoleylcarnitine), emerged as potential novel markers for diagnosis and treatment. CONCLUSIONS: Based on these findings, we posit that the results obtained in this study will aid in diagnosing, treating, and monitoring systemic diseases, and provide a foundation for more comprehensive future molecular studies aimed at enhancing prevention and treatment strategies for infertility.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Proteómica
/
Infertilidad Masculina
Tipo de estudio:
Prognostic_studies
Límite:
Humans
/
Male
Idioma:
En
Revista:
Eur Rev Med Pharmacol Sci
Asunto de la revista:
FARMACOLOGIA
/
TOXICOLOGIA
Año:
2023
Tipo del documento:
Article
País de afiliación:
Turquía
Pais de publicación:
Italia