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Knockdown of LMNA inhibits Akt/ß-catenin-mediated cell invasion and migration in clear cell renal cell carcinoma cells.
Xin, Hui; Tang, Yu; Jin, Yan-Hong; Li, Hu-Li; Tian, Yu; Yu, Cong; Zhao, Ze-Ju; Wu, Ming-Song; Pan, You-Fu.
Afiliación
  • Xin H; Department of Medical Genetics, Zunyi Medical University, Zunyi, Guizhou, China.
  • Tang Y; Key Laboratory of Gene Detection and Treatment in Guizhou Province, Zunyi, Guizhou, China.
  • Jin YH; Department of Medical Genetics, Zunyi Medical University, Zunyi, Guizhou, China.
  • Li HL; Key Laboratory of Gene Detection and Treatment in Guizhou Province, Zunyi, Guizhou, China.
  • Tian Y; Department of Medical Genetics, Zunyi Medical University, Zunyi, Guizhou, China.
  • Yu C; Key Laboratory of Gene Detection and Treatment in Guizhou Province, Zunyi, Guizhou, China.
  • Zhao ZJ; Department of Medical Genetics, Zunyi Medical University, Zunyi, Guizhou, China.
  • Wu MS; Department of Medical Genetics, Zunyi Medical University, Zunyi, Guizhou, China.
  • Pan YF; Department of Medical Genetics, Zunyi Medical University, Zunyi, Guizhou, China.
Cell Adh Migr ; 17(1): 1-14, 2023 12.
Article en En | MEDLINE | ID: mdl-37749865
The LMNA gene encoding lamin A/C is amplified in some clear cell renal cell carcinoma (ccRCC) samples. Our data showed that depletion of the tumor suppressor PBRM1 can upregulate lamin A/C levels, and lamin A/C could interact with PBRM1. However, the role of lamin A/C in ccRCC is not yet fully understood. Our functional assays showed that although the proliferation ability was slightly impaired after LMNA depletion, the migration and invasion of ccRCC cells were significantly inhibited. This suppression was accompanied by a reduction in MMP2, MMP9, AKT/p-AKT, and Wnt/ß-catenin protein levels. Our data therefore suggest that lamin A/C, as an interaction partner of the tumor suppressor PBRM1, plays a crucial role in tumor invasion and metastasis in ccRCC.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma de Células Renales / Neoplasias Renales Límite: Humans Idioma: En Revista: Cell Adh Migr Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
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Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma de Células Renales / Neoplasias Renales Límite: Humans Idioma: En Revista: Cell Adh Migr Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos