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Preoperative lymphocyte count, neutrophil to lymphocyte and platelet to lymphocyte ratio predict the recurrence with progression and cancerization in vocal fold lesions-retrospective study.
Rzepakowska, Anna; Pietruszewska, Wioletta; Zurek, Michal; Molga-Magusiak, Maria; Leszczynski, Michal; Niemczyk, Kazimierz.
Afiliación
  • Rzepakowska A; Department of Otorhinolaryngology Head and Neck Surgery, Medical University of Warsaw, Warsaw, Poland.
  • Pietruszewska W; Department of Otiatrics, Laryngology and Laryngological Oncology, Medical University of Lódz, Lódz, Poland.
  • Zurek M; Department of Otorhinolaryngology Head and Neck Surgery, Medical University of Warsaw, Warsaw, Poland.
  • Molga-Magusiak M; Doctoral School, Medical University of Warsaw, Warsaw, Poland.
  • Leszczynski M; Department of Otorhinolaryngology Head and Neck Surgery, Medical University of Warsaw, Warsaw, Poland.
  • Niemczyk K; Department of Otorhinolaryngology Head and Neck Surgery, Medical University of Warsaw, Warsaw, Poland.
PeerJ ; 11: e15642, 2023.
Article en En | MEDLINE | ID: mdl-37744219
Backgrounds: This study explored the contribution of peripheral blood markers in diagnosis and prognosis estimation of different stages of laryngeal dysplasia and early glottic cancer. Methods: Retrospective analysis of clinical, histopathological and laboratory data of 220 patients including hemoglobin, neutrophil, lymphocyte, monocyte and platelet counts, neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR). Results: The mean hemoglobin level and platelets count showed differences between histopathological stages of lesions (p = 0.041 and 0.046, respectively). In patients with recurrent lesions mean level of lymphocyte count, NLR and PLR were significant in assessing progression and cancerization (p = 0.005, 0.028 and 0.023, respectively). The univariate analysis recognized level of PLR ≥ 141.74 as significant risk factor of the recurrence of vocal fold hypertrophic lesions (OR = 1.963). Conclusions: The levels of blood cells and their ratios seem to be effective in predicting the recurrence of lesion and even more their potential role in indicating malignant progression.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plaquetas / Neutrófilos Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: PeerJ Año: 2023 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plaquetas / Neutrófilos Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: PeerJ Año: 2023 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Estados Unidos