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Analyzing the impact and mechanism of bisphenol A on testicular lipid metabolism in Gobiocypris rarus through integrated lipidomics and transcriptomics.
Zhang, Jianlu; Zhu, Zhu; Huang, Jiqin; Yang, Hui; Wang, Qijun; Zhang, Yingying.
Afiliación
  • Zhang J; Shaanxi key laboratory of Qinling Ecological Security, Shaanxi Institute of Zoology, Xi'an 710032, China; College of Urban and Environmental Sciences, Northwest University, Xi'an 710127, China.
  • Zhu Z; College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China.
  • Huang J; Shaanxi key laboratory of Qinling Ecological Security, Shaanxi Institute of Zoology, Xi'an 710032, China.
  • Yang H; College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China.
  • Wang Q; Shaanxi key laboratory of Qinling Ecological Security, Shaanxi Institute of Zoology, Xi'an 710032, China. Electronic address: wangqijun@xab.ac.cn.
  • Zhang Y; College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China. Electronic address: zhangyingying@yzu.edu.cn.
Ecotoxicol Environ Saf ; 265: 115498, 2023 Oct 15.
Article en En | MEDLINE | ID: mdl-37742580
Bisphenol A (BPA) is one of the most common environmental endocrine chemicals, known for its estrogenic effects that can interfere with male spermatogenesis. Lipids play crucial roles in sperm production, capacitation, and motility as important components of the sperm plasma membrane. However, limited research has explored whether BPA affects lipid metabolism in the testes of male fish and subsequently impacts spermatogenesis. In this study, we employed Gobiocypris rarus rare minnow as a research model and exposed them to environmentally relevant concentrations of BPA (15 µg/L) for 5 weeks. We assessed sperm morphology and function and analyzed changes in testicular lipid composition and transcriptomics. The results demonstrated a significant increase in the sperm head membrane damage rate, along with reduced sperm motility and fertilization ability due to BPA exposure. Lipidomics analysis revealed that BPA increased the content of 11 lipids while decreasing the content of 6 lipids in the testes, particularly within glycerophospholipids, glycerolipids, and sphingolipid subclasses. Transcriptomics results indicated significant up-regulation in pathways such as cholesterol metabolism, peroxisome proliferator-activated receptor signaling, and fat digestion and absorption, with significant alterations in key genes related to lipid metabolism, including apolipoprotein A-I, apolipoprotein C-I, and translocator protein. These findings suggest that BPA exposure can induce testicular lipid metabolism disruption in rare minnows, potentially resulting in abnormalities in rare minnow spermatogenesis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Ecotoxicol Environ Saf Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Ecotoxicol Environ Saf Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos