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Tolerability of endometriosis medical treatment: a comparison between combined hormonal contraceptives and progestins.
da Costa Pinheiro, Denise Joffily Pereira; Pereira, Ana Maria Gomes; Antonini, Marcelo; Maria Albuquerque Salgado, Isabella; Dias, Alexandre Torchio; Lopes, Reginaldo Guedes Coelho.
Afiliación
  • da Costa Pinheiro DJP; Hospital Do Servidor Público Estadual - Francisco Morato de Oliveira (HSPE-FMO), Rua Pedro de Toledo 1800, São Paulo, SP, 04029000, Brazil. denisejoffily@gmail.com.
  • Pereira AMG; CEDEP - Instituto de Assistência Médica ao Servidor Público Estadual (IAMSPE), São Paulo, Brazil. denisejoffily@gmail.com.
  • Antonini M; Hospital Do Servidor Público Estadual - Francisco Morato de Oliveira (HSPE-FMO), Rua Pedro de Toledo 1800, São Paulo, SP, 04029000, Brazil.
  • Maria Albuquerque Salgado I; Hospital Do Servidor Público Estadual - Francisco Morato de Oliveira (HSPE-FMO), Rua Pedro de Toledo 1800, São Paulo, SP, 04029000, Brazil.
  • Dias AT; Hospital Do Servidor Público Estadual - Francisco Morato de Oliveira (HSPE-FMO), Rua Pedro de Toledo 1800, São Paulo, SP, 04029000, Brazil.
  • Lopes RGC; CEDEP - Instituto de Assistência Médica ao Servidor Público Estadual (IAMSPE), São Paulo, Brazil.
BMC Womens Health ; 23(1): 510, 2023 09 23.
Article en En | MEDLINE | ID: mdl-37741998
Endometriosis is a chronic inflammatory disease that occurs in women of reproductive age. Much of the treatment involves hormone therapy that suppresses the proliferation of endometriosis lesions.Objective To compare discontinuation rates of pharmacological treatment with estrogen-progestins and progestins medications. The secondary objective is to evaluate the main side effects of these drugs in patients with endometriosis.Methods This retrospective study analyzed data from 330 patients who attended the Hospital of the State Public Servant of São Paulo from August 1999 to September 2020 and received pharmacological treatment for endometriosis. The data were obtained by review of the files of medical appointments with specialized staff.Results The median treatment time was 18 months, ranging from 1 to 168 months, and 177 patients interrupted the proposed treatment. The combined contraceptives with estrogens and progestins were significantly linked to treatment interruption, with a relative risk of 1,99 (p = 0,005). The most important side effects that resulted in treatment interruption were pain persistence (p = 0,043), weight gain (p = 0,017) and spotting (p < 0,001).
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Efectos Colaterales y Reacciones Adversas Relacionados con Medicamentos / Endometriosis Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies Límite: Female / Humans País/Región como asunto: America do sul / Brasil Idioma: En Revista: BMC Womens Health Asunto de la revista: SAUDE DA MULHER Año: 2023 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Efectos Colaterales y Reacciones Adversas Relacionados con Medicamentos / Endometriosis Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies Límite: Female / Humans País/Región como asunto: America do sul / Brasil Idioma: En Revista: BMC Womens Health Asunto de la revista: SAUDE DA MULHER Año: 2023 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido