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Cerebrospinal fluid-administered therapies for leptomeningeal metastases from solid tumors.
Baskaran, Archit B; Bhatia, Ankush; Kumthekar, Priya; Boire, Adrienne; Lukas, Rimas V.
Afiliación
  • Baskaran AB; Resident, Department of Neurology, The University of Chicago Medicine, Chicago, IL 60637, USA.
  • Bhatia A; Section Head of Neuro-Oncology, Department of Neurology, Medicine, & Human Oncology, University of Wisconsin School of Medicine & Public Health, Madison, WI 53705, USA.
  • Kumthekar P; Department of Neurology, Lou & Jean Malnati Brain Tumor Institute, Northwestern University, Chicago, IL 60611, USA.
  • Boire A; Geoffrey Beene Junior Faculty Chair, Department of Neurology, Human Oncology & Pathogenesis Program, Brain Tumor Center, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • Lukas RV; Neuro-Oncology Division, Associate Professor, Regional Ambulatory Medical Director, Neurology, Department of Neurology, Lou & Jean Malnati Brain Tumor Institute, Northwestern University, Chicago, IL 60611, USA.
Future Oncol ; 19(26): 1801-1807, 2023 Aug.
Article en En | MEDLINE | ID: mdl-37737023
This paper summarizes the findings from 48 clinical trials conducted since the 1970s about the treatment of leptomeningeal metastases through an intrathecal approach (administering drugs directly into the cerebrospinal fluid ­ a fluid that surrounds the brain and spinal cord). The results of these studies suggest that although these therapies show promise for the future, they currently do not clearly and consistently report a benefit. Further work is needed to explore the possible use of these treatments.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Líquido Cefalorraquídeo / Neoplasias Meníngeas / Neoplasias Límite: Humans Idioma: En Revista: Future Oncol Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Líquido Cefalorraquídeo / Neoplasias Meníngeas / Neoplasias Límite: Humans Idioma: En Revista: Future Oncol Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido