Your browser doesn't support javascript.
loading
A Versatile PDA(DOX) Nanoplatform for Chemo-Photothermal Synergistic Therapy against Breast Cancer and Attenuated Doxorubicin-Induced Cardiotoxicity.
Geng, Siqi; Feng, Qiang; Wang, Chujie; Li, Ying; Qin, Jiaying; Hou, Mingsheng; Zhou, Jiedong; Pan, Xiaoyu; Xu, Fei; Fang, Baoru; Wang, Ke; Yu, Zhangsen.
Afiliación
  • Geng S; School of Life and Environmental Sciences, Shaoxing University, Shaoxing, Zhejiang, 312000, People's Republic of China.
  • Feng Q; Laboratory of Nanomedicine, Medical Science Research Center, School of Medicine, Shaoxing University, Shaoxing, Zhejiang, 312000, People's Republic of China.
  • Wang C; Laboratory of Nanomedicine, Medical Science Research Center, School of Medicine, Shaoxing University, Shaoxing, Zhejiang, 312000, People's Republic of China.
  • Li Y; Laboratory of Nanomedicine, Medical Science Research Center, School of Medicine, Shaoxing University, Shaoxing, Zhejiang, 312000, People's Republic of China.
  • Qin J; Laboratory of Nanomedicine, Medical Science Research Center, School of Medicine, Shaoxing University, Shaoxing, Zhejiang, 312000, People's Republic of China.
  • Hou M; Laboratory of Nanomedicine, Medical Science Research Center, School of Medicine, Shaoxing University, Shaoxing, Zhejiang, 312000, People's Republic of China.
  • Zhou J; Department of Pathology, Shaoxing Hospital of Traditional Chinese Medicine, Shaoxing, Zhejiang, 312000, People's Republic of China.
  • Pan X; Laboratory of Nanomedicine, Medical Science Research Center, School of Medicine, Shaoxing University, Shaoxing, Zhejiang, 312000, People's Republic of China.
  • Xu F; Laboratory of Nanomedicine, Medical Science Research Center, School of Medicine, Shaoxing University, Shaoxing, Zhejiang, 312000, People's Republic of China.
  • Fang B; Department of Ultrasound, Affiliated Hospital of Shaoxing University, Shaoxing, Zhejiang, 312000, People's Republic of China.
  • Wang K; School of Life and Environmental Sciences, Shaoxing University, Shaoxing, Zhejiang, 312000, People's Republic of China.
  • Yu Z; Laboratory of Nanomedicine, Medical Science Research Center, School of Medicine, Shaoxing University, Shaoxing, Zhejiang, 312000, People's Republic of China.
J Nanobiotechnology ; 21(1): 338, 2023 Sep 21.
Article en En | MEDLINE | ID: mdl-37735669
Photothermal therapy (PTT) is a highly clinical application promising cancer treatment strategy with safe, convenient surgical procedures and excellent therapeutic efficacy on superficial tumors. However, a single PTT is difficult to eliminate tumor cells completely, and tumor recurrence and metastasis are prone to occur in the later stage. Chemo-photothermal synergistic therapy can conquer the shortcomings by further killing residual tumor cells after PTT through systemic chemotherapy. Nevertheless, chemotherapy drugs' extreme toxicity is also a problematic issue to be solved, such as anthracycline-induced cardiotoxicity. Herein, we selected polydopamine nanoparticles (PDA) as the carrier of the chemotherapeutic drug doxorubicin (DOX) to construct a versatile PDA(DOX) nanoplatform for chemo-photothermal synergistic therapy against breast cancer and simultaneously attenuated DOX-induced cardiotoxicity (DIC). The excellent photothermal properties of PDA were used to achieve the thermal ablation of tumors. DOX carried out chemotherapy to kill residual and occult distant tumors. Furthermore, the PDA(DOX) nanoparticles significantly alleviate DIC, which benefits from PDA's excellent antioxidant enzyme activity. The experimental data of the chemotherapy groups showed that the results of the PDA(DOX) group were much better than the DOX group. This study not only effectively inhibits cancer but tactfully attenuates DIC, bringing a new perspective into synergistic therapy against breast cancer.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hipertermia Inducida / Neoplasias Tipo de estudio: Etiology_studies Límite: Humans Idioma: En Revista: J Nanobiotechnology Año: 2023 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hipertermia Inducida / Neoplasias Tipo de estudio: Etiology_studies Límite: Humans Idioma: En Revista: J Nanobiotechnology Año: 2023 Tipo del documento: Article Pais de publicación: Reino Unido