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Evaluation of Non-Compressive Transvaginal Cervical Elastography as a Quantitative Imaging Biomarker in Pregnancy: A Repeatability and Reliability Analysis.
Janssen, Matthew K; Koelper, Nathan; Weatherby, Michele; Werth, Christina; Schwartz, Nadav.
Afiliación
  • Janssen MK; Maternal Fetal Medicine Research Program, Department of Obstetrics and Gynecology, The University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
  • Koelper N; Center for Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Weatherby M; Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Werth C; Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Schwartz N; Maternal Fetal Medicine Research Program, Department of Obstetrics and Gynecology, The University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
J Ultrasound Med ; 43(1): 33-43, 2024 Jan.
Article en En | MEDLINE | ID: mdl-37732906
OBJECTIVES: Non-compressive strain elastography has been proposed as a novel quantitative imaging biomarker for assessing the structure and function of the cervix. The current study aims to assess the repeatability, and intra- and inter-observer reliability of transvaginal non-compressive cervical strain elastography in a clinical setting. METHODS: We conducted a dual-phase single-center prospective feasibility study of singleton gestations >16-weeks gestation that required a clinically-indicated transvaginal ultrasound. Each study participant, n = 43 in phase 1 and n = 13 in phase 2, had elastography performed by two trained observers that each performed multiple image acquisitions. We performed a multivariable regression to adjust for changes in clinical characteristics between study phases and calculated the repeatability coefficients, limits of agreement, and intraclass correlations for each quantitative elastography parameter. We compared quantitative elastography parameters to cervical length measurements, acquired from the same images. RESULTS: The repeatability coefficients and percent limits of agreement were wide for all of the quantitative elastography parameters, demonstrating poor repeatability. Intraclass correlation coefficients were poor-moderate for both intra-observer (0.31-0.77) and inter-observer reliability (0.35-0.77) in both study phases, while cervical length showed excellent reliability with intraclass correlations consistently >0.90. CONCLUSIONS: Non-compressive transvaginal strain cervical elastography did not demonstrate adequate repeatability or reliability. Our results highlight the importance of rigorously assessing novel quantitative imaging biomarkers before clinical application.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cuello del Útero / Diagnóstico por Imagen de Elasticidad Límite: Female / Humans / Pregnancy Idioma: En Revista: J Ultrasound Med Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cuello del Útero / Diagnóstico por Imagen de Elasticidad Límite: Female / Humans / Pregnancy Idioma: En Revista: J Ultrasound Med Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido