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Prevalence of vitamin B12 deficiency in type 2 diabetic patients taking metformin, a cross-sectional study in primary healthcare.
Al Quran, Thekraiat; Khader, Ateka; Allan, Hadeel; Al-Momani, Rua'a; Aqel, Hamzeh T; Alsaleh, Mu'taz; Bataineh, Ziad.
Afiliación
  • Al Quran T; Faculty of Medicine, Department of Public Health and Family Medicine, Jordan University of Science and Technology, Irbid, Jordan.
  • Khader A; Hijjawi Faculty for Engineering Technology, Department of Biomedical Systems and Informatics Engineering, Yarmouk University, Irbid, Jordan.
  • Allan H; Faculty of Medicine, Department of Public Health and Family Medicine, Jordan University of Science and Technology, Irbid, Jordan.
  • Al-Momani R; Faculty of Medicine, Department of Public Health and Family Medicine, Jordan University of Science and Technology, Irbid, Jordan.
  • Aqel HT; Faculty of Medicine, Department of Public Health and Family Medicine, Jordan University of Science and Technology, Irbid, Jordan.
  • Alsaleh M; Faculty of Medicine, Department of Anesthesia and Recovery, Jordan University of Science and Technology, Irbid, Jordan.
  • Bataineh Z; Faculty of Medicine, Department of General Surgery, Jordan University of Science and Technology, Irbid, Jordan.
Front Endocrinol (Lausanne) ; 14: 1226798, 2023.
Article en En | MEDLINE | ID: mdl-37732117
Background: Several studies documented that metformin use contributes to vitamin B12 deficiency in patients with type 2 diabetes mellitus (T2DM). However, there has been a lack of data assessing this issue in Jordan. Aims: Assess the vitamin B12 serum levels, frequency of vitamin B12 deficiency, and related factors among Jordanian patients with T2DM patients treated with metformin. Methods: a total of 447 subjects attending a primary health care center were included in this cross-sectional study consisting of T2DM patients who use metformin and a control group of non-diabetics. Serum B12 levels were evaluated and B12 deficiency was defined as serum B12 levels ≤ 200 pmol/L. Associations of B12 serum levels or B12 deficiency with other factors like gender, age, and duration of T2DM were analyzed. Results: There was no significant difference in serum B12 levels nor the frequency of vitamin B12 deficiency between T2DM metformin-treated patients and control groups. Among metformin-treated patients there was no difference relating to age, type 2 diabetes mellitus duration, proton pump inhibitors use, and metformin use (duration, dose) between patients with or without B12 deficiency. Conclusion: The prevalence of vitamin B12 deficiency among T2DM patients on metformin treatment in this study was high (48.9%). However, the treatment with metformin and the dose of metformin use was not associated with vitamin B12 deficiency.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Deficiencia de Vitamina B 12 / Diabetes Mellitus Tipo 2 / Metformina Tipo de estudio: Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Front Endocrinol (Lausanne) Año: 2023 Tipo del documento: Article País de afiliación: Jordania Pais de publicación: Suiza
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Deficiencia de Vitamina B 12 / Diabetes Mellitus Tipo 2 / Metformina Tipo de estudio: Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Front Endocrinol (Lausanne) Año: 2023 Tipo del documento: Article País de afiliación: Jordania Pais de publicación: Suiza