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Amphiregulin normalizes altered circuit connectivity for social dominance of the CRTC3 knockout mouse.
Park, Ji-Seon; Heo, Hwon; Kim, Min-Seok; Lee, Seung-Eun; Park, Sukyoung; Kim, Ki-Hyun; Kang, Young-Ho; Kim, Je Seong; Sung, Young Hoon; Shim, Woo Hyun; Kim, Dong-Hou; Song, Youngsup; Yoon, Seung-Yong.
Afiliación
  • Park JS; ADEL Institute of Science & Technology (AIST), ADEL, Inc., Seoul, South Korea.
  • Heo H; Department of Medical Science, Asan Medical Institute of Convergence Science and Technology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
  • Kim MS; Department of Brain Science, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
  • Lee SE; Department of Brain Science, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
  • Park S; Department of Biomedical Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
  • Kim KH; Department of Biomedical Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
  • Kang YH; Department of Biomedical Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
  • Kim JS; Department of Biomedical Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
  • Sung YH; Department of Cell and Genetic Engineering, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
  • Shim WH; Department of Medical Science, Asan Medical Institute of Convergence Science and Technology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
  • Kim DH; Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
  • Song Y; Department of Brain Science, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
  • Yoon SY; Department of Biomedical Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea. ysong@amc.seoul.kr.
Mol Psychiatry ; 28(11): 4655-4665, 2023 Nov.
Article en En | MEDLINE | ID: mdl-37730843
Social hierarchy has a profound impact on social behavior, reward processing, and mental health. Moreover, lower social rank can lead to chronic stress and often more serious problems such as bullying victims of abuse, suicide, or attack to society. However, its underlying mechanisms, particularly their association with glial factors, are largely unknown. In this study, we report that astrocyte-derived amphiregulin plays a critical role in the determination of hierarchical ranks. We found that astrocytes-secreted amphiregulin is directly regulated by cAMP response element-binding (CREB)-regulated transcription coactivator 3 (CRTC3) and CREB. Mice with systemic and astrocyte-specific CRTC3 deficiency exhibited a lower social rank with reduced functional connectivity between the prefrontal cortex, a major social hierarchy center, and the parietal cortex. However, this effect was reversed by astrocyte-specific induction of amphiregulin expression, and the epidermal growth factor domain was critical for this action of amphiregulin. These results provide evidence of the involvement of novel glial factors in the regulation of social dominance and may shed light on the clinical application of amphiregulin in the treatment of various psychiatric disorders.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Factores de Transcripción / Transducción de Señal Límite: Animals Idioma: En Revista: Mol Psychiatry Asunto de la revista: BIOLOGIA MOLECULAR / PSIQUIATRIA Año: 2023 Tipo del documento: Article País de afiliación: Corea del Sur Pais de publicación: Reino Unido
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Factores de Transcripción / Transducción de Señal Límite: Animals Idioma: En Revista: Mol Psychiatry Asunto de la revista: BIOLOGIA MOLECULAR / PSIQUIATRIA Año: 2023 Tipo del documento: Article País de afiliación: Corea del Sur Pais de publicación: Reino Unido