Human respiratory syncytial virus glycoprotein G expressed from a recombinant vaccinia virus vector protects mice against live-virus challenge.
J Virol
; 60(2): 607-13, 1986 Nov.
Article
en En
| MEDLINE
| ID: mdl-3773052
Recombinant vaccinia virus vectors were constructed which expressed the major surface glycoprotein G of human respiratory syncytial (RS) virus. The biological activity of the G protein expressed from these vectors was assayed. Inoculation of rabbits with live recombinant virus induced high titers of antibody which specifically immunoprecipitated RS virus G protein and was capable of neutralizing RS virus infectivity. Immunization of mice by either the intranasal or the intraperitoneal route with recombinant virus that expressed only the G protein resulted in complete protection of the lower respiratory tract upon subsequent challenge with live RS virus.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Infecciones por Respirovirus
/
Virus Sincitiales Respiratorios
/
Proteínas Virales
/
Glicoproteínas de Membrana
/
Proteínas del Envoltorio Viral
/
Inmunización
Límite:
Animals
/
Humans
Idioma:
En
Revista:
J Virol
Año:
1986
Tipo del documento:
Article
Pais de publicación:
Estados Unidos