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Thermal/ultrasound-triggered release of liposomes loaded with Ganoderma applanatum polysaccharide from microbubbles for enhanced tumour ablation.
Yuan, Jiani; Ding, Lei; Han, Lu; Pang, Lina; Zhang, Peidi; Yang, Xiao; Liu, Haijing; Zheng, Minjuan; Zhang, Yunfei; Luo, Wen.
Afiliación
  • Yuan J; Department of Ultrasound, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
  • Ding L; Department of Ultrasound, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
  • Han L; Department of Ultrasound, Xi'an Central Hospital, Xi'an, China.
  • Pang L; Department of Ultrasound, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
  • Zhang P; Department of Ultrasound, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
  • Yang X; Department of Ultrasound, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
  • Liu H; Department of Ultrasound, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
  • Zheng M; Department of Ultrasound, Xijing Hospital, Fourth Military Medical University, Xi'an, China. Electronic address: zhengmj@fmmu.edu.cn.
  • Zhang Y; Department of Orthopaedics, Second Affiliated Hospital, Fourth Military Medical University, Xi'an, China. Electronic address: tdbone@163.com.
  • Luo W; Department of Ultrasound, Xijing Hospital, Fourth Military Medical University, Xi'an, China. Electronic address: lwdd1234@fmmu.edu.cn.
J Control Release ; 363: 84-100, 2023 11.
Article en En | MEDLINE | ID: mdl-37730090
The effectiveness of thermal ablation for the treatment of liver tumours is limited by the risk of incomplete ablation, which can result in residual tumours. Herein, an enhancement strategy is proposed based on the controlled release of Ganoderma applanatum polysaccharide (GAP) liposome-microbubble complexes (GLMCs) via ultrasound (US)-targeted microbubble destruction (UTMD) and sublethal hyperthermic (SH) field. GLMCs were prepared by conjugating GAP liposomes onto the surface of microbubbles via biotin-avidin linkage. In vitro, UTMD promotes the cellular uptake of liposomes and leads to apoptosis of M2-like macrophages. Secretion of arginase-1 (Arg-1) and transforming growth factor-beta (TGF-ß) by M2-like macrophages decreased. In vivo, restriction of tumour volume was observed in rabbit VX2 liver tumours after treatment with GLMCs via UTMD in GLMCs + SH + US group. The expression levels of CD68 and CD163, as markers of tumour-associated macrophages (TAMs) in the GLMCs + SH + US group were reduced in liver tumour tissue. Decreased Arg-1, TGF-ß, Ki67, and CD31 factors related to tumour cell proliferation and angiogenesis was evident on histological analysis. In conclusion, thermal/US-triggered drug release from GLMCs suppressed rabbit VX2 liver tumour growth in the SH field by inhibiting TAMs, which represents a potential approach to improve the effectiveness of thermal ablation.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Liposomas / Neoplasias Hepáticas Límite: Animals Idioma: En Revista: J Control Release Asunto de la revista: FARMACOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Liposomas / Neoplasias Hepáticas Límite: Animals Idioma: En Revista: J Control Release Asunto de la revista: FARMACOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos