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The morphogenic protein CopD controls the spatio-temporal dynamics of PBP1a and PBP2b in Streptococcus pneumoniae.
Lenoir, Cassandra; Pelletier, Anaïs; Manuse, Sylvie; Millat, Hugo; Ducret, Adrien; Galinier, Anne; Doan, Thierry; Grangeasse, Christophe.
Afiliación
  • Lenoir C; Molecular Microbiology and Structural Biochemistry, UMR, Université de Lyon, CNRS , Lyon, France.
  • Pelletier A; Molecular Microbiology and Structural Biochemistry, UMR, Université de Lyon, CNRS , Lyon, France.
  • Manuse S; Molecular Microbiology and Structural Biochemistry, UMR, Université de Lyon, CNRS , Lyon, France.
  • Millat H; Molecular Microbiology and Structural Biochemistry, UMR, Université de Lyon, CNRS , Lyon, France.
  • Ducret A; Molecular Microbiology and Structural Biochemistry, UMR, Université de Lyon, CNRS , Lyon, France.
  • Galinier A; Laboratoire de Chimie Bactérienne, UMR, Aix-Marseille Université, CNRS , Marseille, France.
  • Doan T; Laboratoire d'Ingénierie des Systèmes Macromoléculaires, UMR, Aix-Marseille Université , Marseille, France.
  • Grangeasse C; Molecular Microbiology and Structural Biochemistry, UMR, Université de Lyon, CNRS , Lyon, France.
mBio ; 14(5): e0141123, 2023 Oct 31.
Article en En | MEDLINE | ID: mdl-37728370
IMPORTANCE: Penicillin-binding proteins (PBPs) are essential for proper bacterial cell division and morphogenesis. The genome of Streptococcus pneumoniae encodes for two class B PBPs (PBP2x and 2b), which are required for the assembly of the peptidoglycan framework and three class A PBPs (PBP1a, 1b and 2a), which remodel the peptidoglycan mesh during cell division. Therefore, their activities should be finely regulated in space and time to generate the pneumococcal ovoid cell shape. To date, two proteins, CozE and MacP, are known to regulate the function of PBP1a and PBP2a, respectively. In this study, we describe a novel regulator (CopD) that acts on both PBP1a and PBP2b. These findings provide valuable information for understanding bacterial cell division. Furthermore, knowing that ß-lactam antibiotic resistance often arises from PBP mutations, the characterization of such a regulator represents a promising opportunity to develop new strategies to resensitize resistant strains.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Streptococcus pneumoniae / Peptidil Transferasas Tipo de estudio: Prognostic_studies Idioma: En Revista: MBio Año: 2023 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Streptococcus pneumoniae / Peptidil Transferasas Tipo de estudio: Prognostic_studies Idioma: En Revista: MBio Año: 2023 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Estados Unidos