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Changes in gut microbiota composition after 12 weeks of a home-based lifestyle intervention in breast cancer survivors during the COVID-19 lockdown.
Donati Zeppa, Sabrina; Natalucci, Valentina; Agostini, Deborah; Vallorani, Luciana; Amatori, Stefano; Sisti, Davide; Rocchi, Marco B L; Pazienza, Valerio; Perri, Francesco; Villani, Annacandida; Binda, Elena; Panebianco, Concetta; Mencarelli, Gandino; Ciuffreda, Luigi; Ferri Marini, Carlo; Annibalini, Giosué; Lucertini, Francesco; Bartolacci, Alessia; Imperio, Marta; Virgili, Edy; Catalano, Vincenzo; Piccoli, Giovanni; Stocchi, Vilberto; Emili, Rita; Barbieri, Elena.
Afiliación
  • Donati Zeppa S; Department of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy.
  • Natalucci V; Department of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy.
  • Agostini D; Department of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy.
  • Vallorani L; Department of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy.
  • Amatori S; Department of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy.
  • Sisti D; Department of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy.
  • Rocchi MBL; Department of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy.
  • Pazienza V; Division of Gastroenterology, Fondazione IRCCS "Casa Sollievo della Sofferenza" Hospital, San Giovanni Rotondo, Italy.
  • Perri F; Division of Gastroenterology, Fondazione IRCCS "Casa Sollievo della Sofferenza" Hospital, San Giovanni Rotondo, Italy.
  • Villani A; Division of Gastroenterology, Fondazione IRCCS "Casa Sollievo della Sofferenza" Hospital, San Giovanni Rotondo, Italy.
  • Binda E; Cancer Stem Cells Unit, Institute for Stem Cell Biology, Regenerative Medicine and Innovative Therapeutics (ISBReMIT), IRCSS Casa Sollievo della Sofferenza, Opera di San Pio da Pietrelcina, San Giovanni Rotondo, Italy.
  • Panebianco C; Division of Gastroenterology, Fondazione IRCCS "Casa Sollievo della Sofferenza" Hospital, San Giovanni Rotondo, Italy.
  • Mencarelli G; Cancer Stem Cells Unit, Institute for Stem Cell Biology, Regenerative Medicine and Innovative Therapeutics (ISBReMIT), IRCSS Casa Sollievo della Sofferenza, Opera di San Pio da Pietrelcina, San Giovanni Rotondo, Italy.
  • Ciuffreda L; Breast Surgery Unit, Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy.
  • Ferri Marini C; Department of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy.
  • Annibalini G; Department of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy.
  • Lucertini F; Department of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy.
  • Bartolacci A; Department of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy.
  • Imperio M; Department of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy.
  • Virgili E; School of Biosciences and Veterinary Medicine, University of Camerino, Camerino, Italy.
  • Catalano V; U.O.C. Oncologia Medica, ASUR Area Vasta 1, Ospedale Santa Maria della Misericordia di Urbino, Urbino, Italy.
  • Piccoli G; Department of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy.
  • Stocchi V; Università Telematica San Raffaele, Rome, Italy.
  • Emili R; U.O.C. Oncologia Medica, ASUR Area Vasta 1, Ospedale Santa Maria della Misericordia di Urbino, Urbino, Italy.
  • Barbieri E; Department of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy.
Front Oncol ; 13: 1225645, 2023.
Article en En | MEDLINE | ID: mdl-37727203
Background: Breast cancer (BC) is the second-leading cause of cancer-related death worldwide. This study aimed to investigate the effects of a 12-week home-based lifestyle intervention (based on nutrition and exercise) on gut microbial composition in twenty BC survivors of the MoviS clinical trial (protocol: NCT04818359). Methods: Gut microbiota analysis through 16S rRNA gene sequencing, anthropometrics, Mediterranean Diet (MD) adherence, and cardiometabolic parameters were evaluated before (Pre) and after (Post) the lifestyle intervention (LI). Results: Beneficial effects of the LI were observed on MD adherence, and cardiometabolic parameters (pre vs post). A robust reduction of Proteobacteria was observed after LI, which is able to reshape the gut microbiota by modulating microorganisms capable of decreasing inflammation and others involved in improving the lipid and glycemic assets of the host. A significant negative correlation between fasting glucose and Clostridia_vadinBB60 (r = -0.62), insulin and homeostatic model assessment (HOMA) index and Butyricicoccus genera (r = -0.72 and -0.66, respectively), and HDL cholesterol and Escherichia/Shigella (r = -0.59) have been reported. Moreover, positive correlations were found between MD adherence and Lachnospiraceae_ND3007 (r = 0.50), Faecalibacterium (r = 0.38) and Butyricimonas (r = 0.39). Conclusion: These data suggest that adopting a healthy lifestyle, may contribute to ameliorate several biological parameters that could be involved in the prevention of cancer relapses through the modulation of gut microbiota.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Guideline Idioma: En Revista: Front Oncol Año: 2023 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Guideline Idioma: En Revista: Front Oncol Año: 2023 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza