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Polygenic risk for neuroticism is associated with less efficient control in more difficult situations.
Park, Heekyeong; Forthman, Katherine L; Kuplicki, Rayus; Victor, Teresa A; Yeh, Hung-Wen; Thompson, Wesley K; Howlett, Jonathon R; Guinjoan, Salvador; Paulus, Martin P.
Afiliación
  • Park H; Department of Psychology, University of North Texas at Dallas, TX 75241, USA; Laureate Institute for Brain Research, Tulsa, OK 74136, USA. Electronic address: Heekyeong.Park@untdallas.edu.
  • Forthman KL; Laureate Institute for Brain Research, Tulsa, OK 74136, USA.
  • Kuplicki R; Laureate Institute for Brain Research, Tulsa, OK 74136, USA.
  • Victor TA; Laureate Institute for Brain Research, Tulsa, OK 74136, USA.
  • Yeh HW; Laureate Institute for Brain Research, Tulsa, OK 74136, USA; Department of Pediatrics, Children's Mercy Hospital, Kansas City, MO 64108, USA.
  • Thompson WK; Laureate Institute for Brain Research, Tulsa, OK 74136, USA.
  • Howlett JR; Department of Psychiatry, Veterans Affairs San Diego Healthcare System, La Jolla, CA 92093, USA.
  • Guinjoan S; Laureate Institute for Brain Research, Tulsa, OK 74136, USA; Department of Psychiatry, Oklahoma University Health Sciences Center at Tulsa, OK 74107, USA.
  • Paulus MP; Laureate Institute for Brain Research, Tulsa, OK 74136, USA; Department of Neuroscience, Oxley College of Health Sciences, University of Tulsa, Tulsa, OK 74119, USA.
Psychiatry Res Neuroimaging ; 335: 111716, 2023 10.
Article en En | MEDLINE | ID: mdl-37717543
Neuroticism is a heritable trait and a risk factor for mental health due to its relevance to poor control of negative events. To examine the relationship between genetic propensity for neuroticism and control processing, we used the polygenic risk score (PRS) approach and a stop signal task during fMRI. We hypothesized that genetic propensity for neuroticism may moderate control processing as a function of control difficulty. PRSs for neuroticism were computed from a transdiagnostic group of individuals (n=406) who completed the stop signal task. The level of control difficulty was a function of the stop signal asynchrony: shorter asynchrony allows easier stopping whereas longer asynchrony makes stopping difficult. The relationship between PRS for neuroticism and neural activity for controlling responses was examined by the stop signal asynchrony. Although PRS for neuroticism did not relate to the overall inhibitory control, individuals with high PRS for neuroticism showed greater activity in left dorsal prefrontal cortex, middle temporal gyrus, and dorsal posterior cingulate cortex for difficult control. Thus, the genetic propensity for neuroticism affects neural processing in a difficult control context, which may help to explain why individuals with high levels of neuroticism exert poor control of negative events in difficult situations.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Corteza Prefrontal / Giro del Cíngulo Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Psychiatry Res Neuroimaging Año: 2023 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Corteza Prefrontal / Giro del Cíngulo Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Psychiatry Res Neuroimaging Año: 2023 Tipo del documento: Article Pais de publicación: Países Bajos