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Alteration of microbial composition in the skin and blood in vasculitis.
Miyata, Ryujin; Miyabe, Chie; Oki, Hiroya; Motooka, Daisuke; Nakamura, Shota; Miyabe, Yoshishige; Takenaka, Yuko; Fukuya, Yasuko; Yudo, Kazuo; Ishiguro, Naoko.
Afiliación
  • Miyata R; Division of Dermatology, Department of Dermatology, Tokyo Women's Medical University, Tokyo, Japan.
  • Miyabe C; Division of Dermatology, Department of Dermatology, Tokyo Women's Medical University, Tokyo, Japan. chie.miyabe@marianna-u.ac.jp.
  • Oki H; Department of Frontier Medicine, Institute of Medical Science, St. Marianna University School of Medicine, 2-16-1 Sugao, Kawasaki City, Kanagawa, Japan. chie.miyabe@marianna-u.ac.jp.
  • Motooka D; Department of Infection Metagenomics, Genome Information Research Center, Osaka University Research Institute for Microbial Diseases, Suita, Japan.
  • Nakamura S; Department of Infection Metagenomics, Genome Information Research Center, Osaka University Research Institute for Microbial Diseases, Suita, Japan.
  • Miyabe Y; Department of Infection Metagenomics, Genome Information Research Center, Osaka University Research Institute for Microbial Diseases, Suita, Japan.
  • Takenaka Y; Department of Immunology and Parasitology, St. Marianna University School of Medicine, Kawasaki, Japan.
  • Fukuya Y; Division of Dermatology, Department of Dermatology, Tokyo Women's Medical University, Tokyo, Japan.
  • Yudo K; Division of Dermatology, Department of Dermatology, Tokyo Women's Medical University, Tokyo, Japan.
  • Ishiguro N; Department of Frontier Medicine, Institute of Medical Science, St. Marianna University School of Medicine, 2-16-1 Sugao, Kawasaki City, Kanagawa, Japan.
Sci Rep ; 13(1): 15317, 2023 09 15.
Article en En | MEDLINE | ID: mdl-37714908
Vasculitis is a systemic autoimmune disease characterized by leukocyte infiltration into blood vessels. Various microorganisms have been associated with the pathogenesis of vasculitis; however, the causal microbial agents and underlying mechanisms are not fully understood, possibly because of the technical limitations of pathogen detection. In the present study, we characterized the microbiome profile of patients with cutaneous vasculitis using comprehensive metagenome shotgun sequencing. We found that the abundance of the SEN virus was increased in the affected skin and serum of patients with vasculitis compared to healthy donors. In particular, the abundance of SEN virus reads was increased in the sera of patients with cutaneous arteritis. Among the bacteria identified, Corynebacteriales was the most differentially associated with vasculitis. Linear discriminant analysis effect size also indicated differences in the microbial taxa between patients with vasculitis and healthy donors. These findings demonstrate that vasculitis is associated with considerable alteration of the microbiome in the blood and skin and suggest a role for the infectious trigger in vasculitis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vasculitis / Actinomycetales Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Sci Rep Año: 2023 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
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PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vasculitis / Actinomycetales Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Sci Rep Año: 2023 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido