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Assessing cancer risk in the anterior part of the prostate using micro-ultrasound: validation of a novel distinct protocol.
Schaer, Sandy; Rakauskas, Arnas; Dagher, Julien; La Rosa, Stefano; Pensa, Jake; Brisbane, Wayne; Marks, Leonard; Kinnaird, Adam; Abouassaly, Robert; Klein, Eric; Thomas, Lewis; Meuwly, Jean-Yves; Parker, Pamela; Roth, Beat; Valerio, Massimo.
Afiliación
  • Schaer S; Unit of Urology, Department of Surgery, Lausanne University Hospital (CHUV), Rue du Bugnon 46, 1011, Lausanne, Switzerland. Sandy.schaer@chuv.ch.
  • Rakauskas A; Unit of Urology, Department of Surgery, Lausanne University Hospital (CHUV), Rue du Bugnon 46, 1011, Lausanne, Switzerland.
  • Dagher J; Institute of Pathology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
  • La Rosa S; Institute of Pathology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
  • Pensa J; Pathology Unit, Department of Medicine and Technological Innovation, University of Insubria, Varese, Italy.
  • Brisbane W; UCLA Institute of Urologic Oncology, Los Angeles, USA.
  • Marks L; UCLA Institute of Urologic Oncology, Los Angeles, USA.
  • Kinnaird A; UCLA Institute of Urologic Oncology, Los Angeles, USA.
  • Abouassaly R; UCLA Institute of Urologic Oncology, Los Angeles, USA.
  • Klein E; Division of Urology, Department of Surgery, University of Alberta, Edmonton, Canada.
  • Thomas L; Glickman Urological & Kidney Institute, Cleveland Clinic, Cleveland, USA.
  • Meuwly JY; Glickman Urological & Kidney Institute, Cleveland Clinic, Cleveland, USA.
  • Parker P; Glickman Urological & Kidney Institute, Cleveland Clinic, Cleveland, USA.
  • Roth B; Unit of Urology, Department of Surgery, Washington University in St-Louis, St-Louis, USA.
  • Valerio M; Department of Radiology, Lausanne University Hospital (CHUC), Lausanne, Switzerland.
World J Urol ; 41(11): 3325-3331, 2023 Nov.
Article en En | MEDLINE | ID: mdl-37712968
PURPOSE: To develop and validate a micro-ultrasound risk score that predicts the likelihood of significant prostate cancer in the anterior zone. METHODS: Patients were enrolled from three expert institutions familiar with micro-ultrasound. The study was conducted in two phases. First, the PRI-MUS anterior score was developed by assessing selected prostate videos from patients who subsequently underwent radical prostatectomy. Second, seven urology readers with varying levels of experience in micro-ultrasound examination evaluated prostate loops according to the PRI-MUS anterior score. Each reader watched the videos and recorded the likelihood of the presence of significant cancer in the anterior part of the prostate in a three-point scale. The coherence among the readers was calculated using the Fleiss kappa and the Cronbach alpha. RESULTS: A total of 102 selected prostate scans were used to develop the risk assessment for anterior zone cancer in the prostate. The score comprised three categories: likely, equivocal, and unlikely. The median (IQR) sensitivity, specificity, positive predictive value, and negative predictive value for the seven readers were 72% (68-84), 68% (64-84), 75% (72-81), and 73% (71-80), respectively. The mean SD ROC AUC was 0.75 ± 2%, while the Fleiss kappa and the Cronbach alpha were 0.179 and 0.56, respectively. CONCLUSION: Micro-ultrasound can detect cancerous lesions in the anterior part of the prostate. When combined with the PRI-MUS protocol to assess the peripheral part, it enables an assessment of the entire prostate gland. Pending external validation, the PRI-MUS anterior score developed in this study might be implemented in clinical practice.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Próstata / Neoplasias de la Próstata Tipo de estudio: Etiology_studies / Guideline / Prognostic_studies / Risk_factors_studies Límite: Humans / Male Idioma: En Revista: World J Urol Año: 2023 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Próstata / Neoplasias de la Próstata Tipo de estudio: Etiology_studies / Guideline / Prognostic_studies / Risk_factors_studies Límite: Humans / Male Idioma: En Revista: World J Urol Año: 2023 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Alemania