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The selected genes NR6A1, RSAD2-CMPK2, and COL3A1 contribute to body size variation in Meishan pigs through different patterns.
Liu, Chenxi; Hou, Liming; Zhao, Qingbo; Zhou, Wuduo; Liu, Kaiyue; Liu, Qian; Zhou, Tengbin; Xu, Binbin; Li, Pinghua; Huang, Ruihua.
Afiliación
  • Liu C; Institute of Swine Science (Key Laboratory of Pig Genetic Resources Evaluation and Utilization, Ministry of Agriculture and Rural Affairs (Nanjing)), Nanjing Agricultural University, Nanjing 210095, China.
  • Hou L; Institute of Swine Science (Key Laboratory of Pig Genetic Resources Evaluation and Utilization, Ministry of Agriculture and Rural Affairs (Nanjing)), Nanjing Agricultural University, Nanjing 210095, China.
  • Zhao Q; Institute of Swine Science (Key Laboratory of Pig Genetic Resources Evaluation and Utilization, Ministry of Agriculture and Rural Affairs (Nanjing)), Nanjing Agricultural University, Nanjing 210095, China.
  • Zhou W; Institute of Swine Science (Key Laboratory of Pig Genetic Resources Evaluation and Utilization, Ministry of Agriculture and Rural Affairs (Nanjing)), Nanjing Agricultural University, Nanjing 210095, China.
  • Liu K; Institute of Swine Science (Key Laboratory of Pig Genetic Resources Evaluation and Utilization, Ministry of Agriculture and Rural Affairs (Nanjing)), Nanjing Agricultural University, Nanjing 210095, China.
  • Liu Q; Institute of Swine Science (Key Laboratory of Pig Genetic Resources Evaluation and Utilization, Ministry of Agriculture and Rural Affairs (Nanjing)), Nanjing Agricultural University, Nanjing 210095, China.
  • Zhou T; Kunshan Animal Disease Prevention and Control Center, Suzhou 215000, China.
  • Xu B; Kunshan Meishan Pig Breeding Co., Ltd., Suzhou 215000, China.
  • Li P; Institute of Swine Science (Key Laboratory of Pig Genetic Resources Evaluation and Utilization, Ministry of Agriculture and Rural Affairs (Nanjing)), Nanjing Agricultural University, Nanjing 210095, China.
  • Huang R; Huaian Academy, Nanjing Agricultural University, Huaian 223001, China.
J Anim Sci ; 1012023 Jan 03.
Article en En | MEDLINE | ID: mdl-37703114
The existing well-known Meishan pig population has been categorized into medium sized (MMS), and small sized (SMS) based on body size, which is a result of artificial selection. MMS is relatively large in all body size traits, but otherwise have highly similar appearance and performance traits. To effectively identify the candidate selected genes that contribute to the body size variation in Meishan pigs, this study collected individuals from all lineages of MMS and SMS for re-sequencing. Additionally, femoral cartilage and liver transcription data were collected from MMS and SMS, respectively, and re-sequencing data from pig breeds exhibiting varying body sizes were also analyzed. Through multi-omics analysis, it was discovered that the missense mutation c.575T > C in the candidate causal gene NR6A1 was positively selected in MMS only, leading to an increase in the body length of MMS at 6 months of age. Moreover, the selected genes RSAD2-CMPK2 and COL3A1 were found to be significantly greater expressed in SMS femoral cartilage and liver tissues compared with MMS. These genes could potentially strengthen bone resorption and metabolism-related pathways in SMS. These findings contribute to a better understanding of the genetic mechanisms underlying body size variation in Meishan pigs and Chinese indigenous pigs.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Nucleósido-Fosfato Quinasa / Colágeno Tipo III / Sitios de Carácter Cuantitativo / Oxidorreductasas actuantes sobre Donantes de Grupo CH-CH / Miembro 1 del Grupo A de la Subfamilia 6 de Receptores Nucleares / Proteína Viperina Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: J Anim Sci Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Nucleósido-Fosfato Quinasa / Colágeno Tipo III / Sitios de Carácter Cuantitativo / Oxidorreductasas actuantes sobre Donantes de Grupo CH-CH / Miembro 1 del Grupo A de la Subfamilia 6 de Receptores Nucleares / Proteína Viperina Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: J Anim Sci Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos