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Evolution of Plasmodium vivax and resistance patterns for infection based on Duffy genotype and phenotype.
Picón-Jaimes, Yelson Alejandro; Lozada-Martinez, Ivan David; Forero Buelvas, María Camila; Ardila Sarmiento, Andrés Felipe; Serrano Baez, Gustavo Adolfo; Nazareno Erazo, Deilly Yohana; Cuastumal Martínez, José Daniel; Ruiz-Gutierrez, Franklin Kevin; Carreño Barrera, Victor Daniel.
Afiliación
  • Picón-Jaimes YA; Fac Ciències Salut Blanquerna, Univ Ramon Llul, Barcelona, Spain.
  • Lozada-Martinez ID; Epidemiology Program, Department of Graduate Studies in Health Sciences, Universidad Autónoma de Bucaramanga, Bucaramanga, Colombia.
  • Forero Buelvas MC; School of Medicine, Universidad Autónoma de Bucaramanga, Bucaramanga, Colombia.
  • Ardila Sarmiento AF; School of Medicine, Universidad Autónoma de Bucaramanga, Bucaramanga, Colombia.
  • Serrano Baez GA; Department of Intensive Care, Clínica de Urgencias Bucaramanga, Bucaramanga, Colombia.
  • Nazareno Erazo DY; Departament of Medicine, Universidad del Cauca, Popayán, Colombia.
  • Cuastumal Martínez JD; Departament of Medicine, Universidad del Cauca, Popayán, Colombia.
  • Ruiz-Gutierrez FK; Department of Intensive Care, Hospital Felix Bulnes Cerda, Santiago de Chile, Chile.
  • Carreño Barrera VD; Department of Medicine, Universidad de Santander, Bucaramanga, Colombia.
Infez Med ; 31(3): 350-358, 2023.
Article en En | MEDLINE | ID: mdl-37701383
The Duffy protein, a transmembrane molecule, acts as a receptor for various chemokines and facilitates binding between reticulocytes and the Plasmodium Duffy antigen binding protein. Duffy expression is associated with the Duffy chemokine receptor antigen genotype on chromosome 1 and exhibits variation across different geographic regions. Traditionally, the Duffy negative genotype and phenotype have been described to confer a certain level of protection against infection and symptom development. However, recent data suggest a shift in this behavior, with significantly higher prevalence observed in individuals with Duffy negative genotype or phenotype. Given that malaria is an endemic vector-borne disease in regions of Asia, Africa, and Latin America, posing a substantial global burden of disease and prioritizing public and global health, identifying evolutionary changes in infection and resistance patterns holds great importance for the design of strategies and reevaluation of conventional interventions. Hence, the aim of this review was to analyze the evolution of Plasmodium vivax and infection resistance patterns based on Duffy genotype and phenotype. The distribution of genotypes, phenotypes, and polymorphisms of P. vivax ligands and erythrocyte receptors varies geographically, notably resistance patterns of this microorganism in individuals with Duffy negative genotype and phenotype have significantly changed compared to studies conducted 30 years ago. The prevalence of vivax malaria in individuals with a Duffy negative status can reach up to 100%. Consequently, prioritizing research on this topic is essential for public health.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Risk_factors_studies Idioma: En Revista: Infez Med Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: España Pais de publicación: Italia
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Risk_factors_studies Idioma: En Revista: Infez Med Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: España Pais de publicación: Italia