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Causal associations between gut microbiota and urological tumors: a two-sample mendelian randomization study.
Mingdong, Wang; Xiang, Gao; Yongjun, Quan; Mingshuai, Wang; Hao, Ping.
Afiliación
  • Mingdong W; Department of Urology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
  • Xiang G; Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
  • Yongjun Q; Department of Urology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
  • Mingshuai W; Department of Urology, Cancer Hospital, Chinese Academy of Medical Sciences, Beijing, China.
  • Hao P; Department of Urology, Beijing Tongren Hospital, Capital Medical University, Beijing, China. pinghaotrh@ccmu.edu.cn.
BMC Cancer ; 23(1): 854, 2023 Sep 11.
Article en En | MEDLINE | ID: mdl-37697271
BACKGROUND: Dysbiosis of gut microbiota has been linked to numerous diseases, including cancer. The unique role of gut microbiota in urological tumors is gaining prominence. However, it is still controversial whether the dysbiosis of gut microbiota should be one of the etiological factors of bladder cancer (BCa), prostate cancer (PCa) or kidney cancer (KCa). MATERIALS AND METHODS: The microbiome genome-wide association study (GWAS) from the MiBioGen consortium (18,340 samples of 24 population-based cohorts) was utilized as the exposure data. Additionally, outcomes data (951 BCa cases and 307,092 controls; 1,631 KCa cases and 238,678 controls; 79,148 PCa cases and 61,106 controls) were extracted from the GWAS of the FinnGen and PRACTICAL consortia. To detect the potential causative bacterial traits for BCa, PCa, and KCa, a two-sample Mendelian randomization (MR) analysis was performed, employing the inverse-variance weighted or Wald ratio method. Sensitivity analyses were subsequently conducted to explore the robustness of the primary results. Finally, the reverse MR analysis was undertaken to mitigate the reverse causation. RESULTS: This study suggested that Bifidobacterium (p = 0.030), Actinobacteria (p = 0.037 for phylum, 0.041 for class), and Ruminococcustorques group (p = 0.018), exhibited an association with an increased risk of BCa using either the inverse-variance weighted or Wald ratio method. By utilizing the Wald ratio method, Allisonella (p = 0.004, p = 0.038) was associated with a decreased risk of BCa and PCa, respectively. Furthermore, Ruminococcustorques group (p = 0.028) and Erysipelatoclostridium (p = 0.048) were causally linked to an elevated risk of KCa. CONCLUSIONS: This MR study supports that genetically predicted gut microbiota is causally related to BCa, PCa and KCa. Additionally, distinct bacterial traits are identified in relation to each tumor type.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma de Células Renales / Neoplasias Urológicas / Microbioma Gastrointestinal / Neoplasias Renales Tipo de estudio: Clinical_trials / Prognostic_studies / Risk_factors_studies Límite: Humans / Male Idioma: En Revista: BMC Cancer Asunto de la revista: NEOPLASIAS Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma de Células Renales / Neoplasias Urológicas / Microbioma Gastrointestinal / Neoplasias Renales Tipo de estudio: Clinical_trials / Prognostic_studies / Risk_factors_studies Límite: Humans / Male Idioma: En Revista: BMC Cancer Asunto de la revista: NEOPLASIAS Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido