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Role of brain metabolites during acute phase of mild traumatic brain injury in prognosis of post-concussion syndrome: A 1H-MRS study.
Dogahe, Mohammad Haghani; Ramezani, Sara; Reihanian, Zoheir; Raminfard, Samira; Feizkhah, Alireza; Alijani, Babak; Herfeh, Sina Sedaghat.
Afiliación
  • Dogahe MH; Guilan Road Trauma Research Center, Guilan University of Medical Sciences, Rasht, Iran.
  • Ramezani S; Guilan Road Trauma Research Center, Guilan University of Medical Sciences, Rasht, Iran; Department of Food Science and Nutrition, California State University, Fresno, CA, USA; Neuroscience Research Center, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran. Electronic address: s.
  • Reihanian Z; Department of Neurosurgery, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
  • Raminfard S; Neuroimaging and Analysis Group, Research Center of Molecular and Cellular Imaging, Tehran University of Medical Sciences, Tehran, Iran.
  • Feizkhah A; Burn and Regenerative Medicine Research Center, Guilan University of Medical Sciences, Rasht, Iran; Department of Medical Physics, Guilan University of Medical Sciences, Rasht, Iran.
  • Alijani B; Guilan Road Trauma Research Center, Guilan University of Medical Sciences, Rasht, Iran; Department of Neurosurgery, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
  • Herfeh SS; Neuroscience Research Center, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
Psychiatry Res Neuroimaging ; 335: 111709, 2023 10.
Article en En | MEDLINE | ID: mdl-37688998
This study has investigated the potency and accuracy of early magnetic resonance spectroscopy (MRS) to predict post-concussion syndrome (PCS) in adult patients with a single mild traumatic brain injury (mTBI) without abnormality on a routine brain scan. A total of 48 eligible mTBI patients and 24 volunteers in the control group participated in this project. Brain MRS over regions of interest (ROI) and signal stop task (SST) were done within the first 72 hours of TBI onset. After six months, PCS appearance and severity were determined. In non-PCS patients, N-acetyl aspartate (NAA) levels significantly increased in the dorsolateral prefrontal cortex (DLPFC) and anterior cingulate cortex (ACC) relative to the control group, however, this increase of NAA levels were recorded in all ROI versus PCS subjects. There were dramatic declines in creatinine (Cr) levels of all ROI and a decrease in choline levels of corpus callosum (CC) in the PCS group versus control and non-PCS ones. NAA and NAA/Cho values in ACC were the main predictors of PCS appearance. The Cho/Cr level in ACC was the first predictor of PCS severity. Predicting accuracy was higher in ACC than in other regions. This study suggested the significance of neuro-markers in ACC for optimal prediction of PCS and rendered a new insight into the biological mechanism of mTBI that underpins PCS.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Conmoción Encefálica / Síndrome Posconmocional Tipo de estudio: Prognostic_studies Límite: Adult / Humans Idioma: En Revista: Psychiatry Res Neuroimaging Año: 2023 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Conmoción Encefálica / Síndrome Posconmocional Tipo de estudio: Prognostic_studies Límite: Adult / Humans Idioma: En Revista: Psychiatry Res Neuroimaging Año: 2023 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Países Bajos