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Circ_0002295 facilitated myocardial fibrosis progression through the miR-1287/CXCR2 axis.
Ma, Guo-Bin; Chen, Wen-Xu; Zhan, Fang-Jie; Xie, Wen-Jing; Chen, Rong-Wei; Chen, Hong; Ye, Wei-Lin; Jiang, Yu; Xu, Jian-Ping.
Afiliación
  • Ma GB; Department of Cardiology, Fuzhou Second Hospital, Fuzhou, China.
  • Chen WX; Department of Clinical Laboratory, Fuzhou Second Hospital, Fuzhou, China.
  • Zhan FJ; Department of Clinical Laboratory, Fuzhou Second Hospital, Fuzhou, China.
  • Xie WJ; Department of Clinical Laboratory, Fuzhou Second Hospital, Fuzhou, China.
  • Chen RW; Department of Clinical Laboratory, Fuzhou Second Hospital, Fuzhou, China.
  • Chen H; Department of Clinical Laboratory, Fuzhou Second Hospital, Fuzhou, China.
  • Ye WL; Department of Clinical Laboratory, Fuzhou Second Hospital, Fuzhou, China.
  • Jiang Y; Department of Clinical Laboratory, Fuzhou Second Hospital, Fuzhou, China.
  • Xu JP; Department of Clinical Laboratory Medicine, Fujian Medical University, Fuzhou, China.
Clin Exp Pharmacol Physiol ; 50(12): 944-953, 2023 12.
Article en En | MEDLINE | ID: mdl-37688444
Myocardial fibrosis (MF) is involved in hypertension, myocardial infarction and heart failure. It has been reported that circular RNA (circRNA) is a key regulatory factor of MF progression. In this study, we revealed that circ_0002295 and CXCR2 were elevated, and miR-1287 was reduced in MF patients. Knockdown of circ_0002295 effectively suppressed the proliferation, migration and MF progression. Circ_0002295 was the molecular sponge of miR-12878, and miR-1287 inhibitor reversed the biological functions of circ_0002295 on the myocardial fibrosis. CXCR2 was a target gene of miR-1287, and CXCR2 silencing relieved the impacts of miR-1287 inhibitor on cardiac myofibroblasts. Circ_0002295 promoted MF progression by regulating the miR-1287/CXCR2 axis, providing a possible circRNA-targeted therapy for MF.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: MicroARNs / Insuficiencia Cardíaca / Infarto del Miocardio Límite: Humans Idioma: En Revista: Clin Exp Pharmacol Physiol Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Australia
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: MicroARNs / Insuficiencia Cardíaca / Infarto del Miocardio Límite: Humans Idioma: En Revista: Clin Exp Pharmacol Physiol Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Australia