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Injectable Decorin/Gellan Gum Hydrogel Encapsulating Adipose-Derived Stem Cells Enhances Anti-Inflammatory Effect in Cartilage Injury via Autophagy Signaling.
He, Weiping; Wu, Yu; Luo, Zhihong; Yang, Genghua; Ye, Woquan; Chen, Xi; Ren, Jianhua; Liang, Tangzhao; Liao, Zhiqiang; Jiang, Shihai; Wang, Kun.
Afiliación
  • He W; Department of Orthopedic Surgery, Dongguan Hospital of Integrated Traditional Chinese and Western Medicine, Dongguan, China.
  • Wu Y; Department of Plastic Surgery, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
  • Luo Z; Department of Orthopedic Surgery, Dongguan Hospital of Integrated Traditional Chinese and Western Medicine, Dongguan, China.
  • Yang G; Department of Orthopedic Surgery, Dongguan Hospital of Integrated Traditional Chinese and Western Medicine, Dongguan, China.
  • Ye W; Department of Orthopedic Surgery, Dongguan Hospital of Integrated Traditional Chinese and Western Medicine, Dongguan, China.
  • Chen X; Department of Joint and Trauma Surgery, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
  • Ren J; Department of Joint and Trauma Surgery, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
  • Liang T; Department of Joint and Trauma Surgery, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
  • Liao Z; Department of Orthopedic Surgery, Dongguan Hospital of Integrated Traditional Chinese and Western Medicine, Dongguan, China.
  • Jiang S; Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Germany.
  • Wang K; Department of Joint and Trauma Surgery, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
Cell Transplant ; 32: 9636897231196493, 2023.
Article en En | MEDLINE | ID: mdl-37688441
Adipose-derived stem cells (ADSCs) are employed as a promising alternative in treating cartilage injury. Regulating the inflammatory "fingerprint" of ADSCs to improve their anti-inflammatory properties could enhance therapy efficiency. Herein, a novel injectable decorin/gellan gum hydrogel combined with ADSCs encapsulation for arthritis cartilage treatment is proposed. Decorin/gellan gum hydrogel was prepared according to the previous manufacturing protocol. The liquid-solid form transition of gellan gum hydrogel is perfectly suitable for intra-articular injection. Decorin-enriched matrix showing an immunomodulatory ability to enhance ADSCs anti-inflammatory phenotype under inflammation microenvironment by regulating autophagy signaling. This decorin/gellan gum/ADSCs hydrogel efficiently reverses interleukin-1ß-induced cellular injury in chondrocytes. Through a mono-iodoacetate-induced arthritis mice model, the synergistic therapeutic effect of this ADSCs-loaded hydrogel, including inflammation attenuation and cartilage protection, is demonstrated. These results make the decorin/gellan gum hydrogel laden with ADSCs an ideal candidate for treating inflammatory joint disorders.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Artritis / Hidrogeles Tipo de estudio: Guideline Límite: Animals Idioma: En Revista: Cell Transplant Asunto de la revista: TRANSPLANTE Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Artritis / Hidrogeles Tipo de estudio: Guideline Límite: Animals Idioma: En Revista: Cell Transplant Asunto de la revista: TRANSPLANTE Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos