Your browser doesn't support javascript.
loading
Suaeda glauca Attenuates Liver Fibrosis in Mice by Inhibiting TGFß1-Smad2/3 Signaling in Hepatic Stellate Cells.
Hong, You-Jung; Kim, Gil-Hwan; Park, Yongdo; Jo, Hye-Jin; Nam, Min-Woo; Kim, Dong-Gu; Cho, Hwangeui; Shim, Hyun-Joo; Jin, Jong-Sik; Rho, Hyunsoo; Han, Chang-Yeob.
Afiliación
  • Hong YJ; Institute of New Drug Development, School of Pharmacy, Jeonbuk National University, Jeonju 54896, Jeonbuk, Republic of Korea.
  • Kim GH; Institute of New Drug Development, School of Pharmacy, Jeonbuk National University, Jeonju 54896, Jeonbuk, Republic of Korea.
  • Park Y; Institute of New Drug Development, School of Pharmacy, Jeonbuk National University, Jeonju 54896, Jeonbuk, Republic of Korea.
  • Jo HJ; Institute of New Drug Development, School of Pharmacy, Jeonbuk National University, Jeonju 54896, Jeonbuk, Republic of Korea.
  • Nam MW; LED Agri-Bio Fusion Technology Research Center, Jeonbuk National University, Iksan 54596, Jeonbuk, Republic of Korea.
  • Kim DG; Department of Oriental Medicine Resources, Jeonbuk National University, Iksan 54596, Jeonbuk, Republic of Korea.
  • Cho H; Institute of New Drug Development, School of Pharmacy, Jeonbuk National University, Jeonju 54896, Jeonbuk, Republic of Korea.
  • Shim HJ; Institute of New Drug Development, School of Pharmacy, Jeonbuk National University, Jeonju 54896, Jeonbuk, Republic of Korea.
  • Jin JS; LED Agri-Bio Fusion Technology Research Center, Jeonbuk National University, Iksan 54596, Jeonbuk, Republic of Korea.
  • Rho H; Department of Oriental Medicine Resources, Jeonbuk National University, Iksan 54596, Jeonbuk, Republic of Korea.
  • Han CY; Institute of New Drug Development, School of Pharmacy, Jeonbuk National University, Jeonju 54896, Jeonbuk, Republic of Korea.
Nutrients ; 15(17)2023 Aug 26.
Article en En | MEDLINE | ID: mdl-37686772
Chronic liver injury due to various hepatotoxic stimuli commonly leads to fibrosis, which is a crucial factor contributing to liver disease-related mortality. Despite the potential benefits of Suaeda glauca (S. glauca) as a natural product, its biological and therapeutic effects are barely known. This study investigated the effects of S. glauca extract (SGE), obtained from a smart farming system utilizing LED lamps, on the activation of hepatic stellate cells (HSCs) and the development of liver fibrosis. C57BL/6 mice received oral administration of either vehicle or SGE (30 or 100 mg/kg) during CCl4 treatment for 6 weeks. The supplementation of SGE significantly reduced liver fibrosis induced by CCl4 in mice as evidenced by histological changes and a decrease in collagen accumulation. SGE treatment also led to a reduction in markers of HSC activation and inflammation as well as an improvement in blood biochemical parameters. Furthermore, SGE administration diminished fibrotic responses following acute liver injury. Mechanistically, SGE treatment prevented HSC activation and inhibited the phosphorylation and nuclear translocation of Smad2/3, which are induced by transforming growth factor (TGF)-ß1 in HSCs. Our findings indicate that SGE exhibits anti-fibrotic effects by inhibiting TGFß1-Smad2/3 signaling in HSCs.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Chenopodiaceae / Células Estrelladas Hepáticas Límite: Animals Idioma: En Revista: Nutrients Año: 2023 Tipo del documento: Article Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Chenopodiaceae / Células Estrelladas Hepáticas Límite: Animals Idioma: En Revista: Nutrients Año: 2023 Tipo del documento: Article Pais de publicación: Suiza