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Comparative Study of the Efficacy of EHO-85, a Hydrogel Containing Olive Tree (Olea europaea) Leaf Extract, in Skin Wound Healing.
Torrecillas-Baena, Bárbara; Camacho-Cardenosa, Marta; Carmona-Luque, María Dolores; Dorado, Gabriel; Berenguer-Pérez, Miriam; Quesada-Gómez, José Manuel; Gálvez-Moreno, María Ángeles; Casado-Díaz, Antonio.
Afiliación
  • Torrecillas-Baena B; Maimonides Institute of Biomedical Research in Cordoba (IMIBIC), 14004 Cordoba, Spain.
  • Camacho-Cardenosa M; Endocrinology and Nutrition Unit, Reina Sofia University Hospital, 14004 Cordoba, Spain.
  • Carmona-Luque MD; CIBER Fragilidad y Envejecimiento Saludable (CIBERFES), Instituto de Salud Carlos III, 28029 Madrid, Spain.
  • Dorado G; Maimonides Institute of Biomedical Research in Cordoba (IMIBIC), 14004 Cordoba, Spain.
  • Berenguer-Pérez M; Endocrinology and Nutrition Unit, Reina Sofia University Hospital, 14004 Cordoba, Spain.
  • Quesada-Gómez JM; Maimonides Institute of Biomedical Research in Cordoba (IMIBIC), 14004 Cordoba, Spain.
  • Gálvez-Moreno MÁ; Cellular Therapy Unit, Reina Sofia University Hospital, 14004 Cordoba, Spain.
  • Casado-Díaz A; CIBER Fragilidad y Envejecimiento Saludable (CIBERFES), Instituto de Salud Carlos III, 28029 Madrid, Spain.
Int J Mol Sci ; 24(17)2023 Aug 28.
Article en En | MEDLINE | ID: mdl-37686133
Olive tree (Olea europaea) leaf extract (OELE) has important antioxidant and anti-inflammatory properties, supporting its use in human clinical practice. We recently designed an amorphous hydrogel called EHO-85 (EHO indicates olive leaf extract in Spanish) containing OELE for skin ulcer treatments. Yet, its effectiveness has not been previously compared with other products used in routine clinical practice. This is necessary to evaluate its potential translation to the human clinic. Thus, in this study, the effect of EHO-85 on healing was evaluated in comparison with treatments containing Indian/Asiatic pennywort (Centella asiatica), hyaluronic acid, or dexpanthenol in a rat model. The speed of wound closure and histological parameters after seven and 14 days were analyzed. All treatments accelerated wound closure, but there were differences between them. Dexpanthenol after seven days produced the highest epithelialization and the lowest inflammation and vascularization. EHO-85 also promoted epithelialization and reduced vascularization. After 14 days, wounds treated with EHO-85 showed less inflammation and higher levels of collagen in the extracellular matrix. This indicates a higher degree of maturity in the regenerated tissue. In conclusion, the effect of EHO-85 on healing was equal to or superior to that of other treatments routinely used in human clinical practice. Therefore, these results, together with previous data on the effects of this hydrogel on ulcer healing in humans, indicate that EHO-85 is a suitable, low-cost, and efficient therapeutic option for wound healing.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Olea Límite: Animals / Humans Idioma: En Revista: Int J Mol Sci Año: 2023 Tipo del documento: Article País de afiliación: España Pais de publicación: Suiza
Texto completo
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Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Olea Límite: Animals / Humans Idioma: En Revista: Int J Mol Sci Año: 2023 Tipo del documento: Article País de afiliación: España Pais de publicación: Suiza