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Body mass index affects the association between plasma lipids and peripheral eosinophils in a general chinese population: a cross-sectional survey.
Gao, Yu; Wang, Xiaocheng; Gao, Lan; Li, Xin; Bai, Weihong.
Afiliación
  • Gao Y; Department of Otorhinolaryngology, Shanxi Provincial People's Hospital Affiliated to Shanxi Medical University, No. 29 of Twin Towers Temple Street, Taiyuan, Shanxi, 030012, China. gaoxing-74@163.com.
  • Wang X; Department of Statistics, Shanxi Provincial People's Hospital Affiliated to Shanxi Medical University, No. 29 of Twin Towers Temple Street, Taiyuan, Shanxi, 030012, China.
  • Gao L; College of Basic Medicine, Shanxi University of Chinese Medicine, Jinzhong, Shanxi, 030619, China.
  • Li X; Department of Otorhinolaryngology, Shanxi Provincial People's Hospital Affiliated to Shanxi Medical University, No. 29 of Twin Towers Temple Street, Taiyuan, Shanxi, 030012, China.
  • Bai W; Department of Otorhinolaryngology, Shanxi Provincial People's Hospital Affiliated to Shanxi Medical University, No. 29 of Twin Towers Temple Street, Taiyuan, Shanxi, 030012, China.
Lipids Health Dis ; 22(1): 146, 2023 Sep 07.
Article en En | MEDLINE | ID: mdl-37679775
BACKGROUND: Lipid metabolism affects type 2 immunity; however, the association between plasma lipids and eosinophilic inflammation in humans is uncertain. This study analysed the relationship between plasma lipids and peripheral eosinophils and whether patterns differ with different body mass indexes (BMI). METHODS: A cross-sectional survey including 62,441 healthy participants recruited from a regular health screening programme was conducted. Participants were divided into normal weight, overweight and obese subgroups according to BMI. RESULTS: Multiple linear regression analysis revealed that elevated logarithmic-transformed eosinophil counts (log(EOS)) significantly correlated with high total cholesterol(TC), triglyceride(TG), low-density lipoprotein-cholesterol (LDL-C), and low high-density lipoprotein-cholesterol (HDL-C)levels in the overall population, as well as in men and women, while certain associations between peripheral blood eosinophil percentage and serum lipids varied by gender. These correlations existed across almost all BMI subgroups, and standardised ß values decreased sequentially with increasing BMI. HDL-C had the most significant effect on eosinophils in obese women. Two-factor analysis of variance showed log(EOS) increased with higher BMI and hyperlipidemia whether in male or female and a synergistic effect exists of lipid levels (TG and LDL-C) and BMI in men. CONCLUSIONS: Blood eosinophil counts were correlated with blood lipid levels and modified by body mass index status. The effects of lipid levels and body mass index on blood eosinophil counts were synergistic. Therefore, lipid metabolism may be involved in systemic eosinophil inflammation.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Índice de Masa Corporal / Eosinófilos / Pueblos del Este de Asia / Inflamación / Lípidos Tipo de estudio: Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Female / Humans / Male Idioma: En Revista: Lipids Health Dis Asunto de la revista: BIOQUIMICA / METABOLISMO Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Índice de Masa Corporal / Eosinófilos / Pueblos del Este de Asia / Inflamación / Lípidos Tipo de estudio: Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Female / Humans / Male Idioma: En Revista: Lipids Health Dis Asunto de la revista: BIOQUIMICA / METABOLISMO Año: 2023 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido