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Developmental neurotoxicity evaluation of three Chinese herbal medicines in zebrafish larvae by means of two behavioral assays: Touch-evoked response and light/dark transition.
Romero, Noelia G; Gutierrez, Gerard; Teixidó, Elisabet; Li, Lu; Klose, Jördis; Leung, Ping Chung; Cañigueral, Salvador; Fritsche, Ellen; Barenys, Marta.
Afiliación
  • Romero NG; GRET and Toxicology Unit, Department of Pharmacology, Toxicology and Therapeutic Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, 08028 Barcelona, Spain; Institute of Nutrition and Food Safety of the University of Barcelona (INSA-UB), Spain.
  • Gutierrez G; GRET and Toxicology Unit, Department of Pharmacology, Toxicology and Therapeutic Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, 08028 Barcelona, Spain.
  • Teixidó E; GRET and Toxicology Unit, Department of Pharmacology, Toxicology and Therapeutic Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, 08028 Barcelona, Spain; Institute of Nutrition and Food Safety of the University of Barcelona (INSA-UB), Spain.
  • Li L; College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China; Department of Obstetrics & Gynaecology, Li Ka Shing Institute of Health Sciences, School of Biomedical Sciences, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong; National Key Laboratory of Chinese Medicine Mod
  • Klose J; IUF - Leibniz Research Institute for Environmental Medicine, Düsseldorf, Germany.
  • Leung PC; Institute of Chinese Medicine, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong.
  • Cañigueral S; Unitat de Farmacologia, Farmacognòsia, i Terapèutica, Facultat de Farmàcia, i Ciències de l'Alimentació, Universitat de Barcelona, Av. Joan XXIII 27-31, 08028 Barcelona, Spain.
  • Fritsche E; IUF - Leibniz Research Institute for Environmental Medicine, Düsseldorf, Germany; Medical Faculty, University of Düsseldorf, 40225 Düsseldorf, Germany; DNTOX GmbH, 40223 Düsseldorf, Germany.
  • Barenys M; GRET and Toxicology Unit, Department of Pharmacology, Toxicology and Therapeutic Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, 08028 Barcelona, Spain; Institute of Nutrition and Food Safety of the University of Barcelona (INSA-UB), Spain; German Centre for the Protection
Reprod Toxicol ; 121: 108469, 2023 10.
Article en En | MEDLINE | ID: mdl-37673194
Chinese herbal medicine (CHM) is used among pregnant women. However, the question of its safety during pregnancy remains unclear. The use of these products relies on history of use data but there are specific toxicities like developmental neurotoxicity that are clearly understudied. Here we use the zebfrafish embryo developmental toxicity assay (ZEDTA) in combination with two behavioral assays: touch-evoked response and Light/Dark (L/D) transition assay to evaluate the neuro/developmental toxicity of three herbal products commonly used in CHM [Chinese name (abbreviation; part of the plant and Scientific name]: tian ma (TM; tuber form Gastrodia elata Blume), lei gong teng (LGT; root and rhizome of Tripterygium wilfordii Hook.f) and cha ye (green tea, leaves from Camellia sinensis (L.) Kuntze). In case significant alterations were detected, single components with potential exposure during pregnancy were identified in the literature and further tested. TM had no neurodevelopmental toxic potential in zebrafish embryos, while LGT and its main compounds triptolide and celastrol induced significant alterations in behavior. Developmental exposure to EGCG, the main catechin of green tea, also produced significant alterations in zebrafish embryos behavior after developmental exposure. A combination of ZEDTA with L/D Transition assay is proposed as a useful combination of alternative methods for DNT assessment of CHM products together with other New Approach Methodologies (NAMs).
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tacto / Pez Cebra Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans / Pregnancy Idioma: En Revista: Reprod Toxicol Asunto de la revista: EMBRIOLOGIA / MEDICINA REPRODUTIVA / TOXICOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: España Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tacto / Pez Cebra Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans / Pregnancy Idioma: En Revista: Reprod Toxicol Asunto de la revista: EMBRIOLOGIA / MEDICINA REPRODUTIVA / TOXICOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: España Pais de publicación: Estados Unidos