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Research progress in the molecular mechanism of ferroptosis in Parkinson's disease and regulation by natural plant products.
Yang, Kailin; Zeng, Liuting; Zeng, Jinsong; Deng, Ying; Wang, Shanshan; Xu, Hao; He, Qi; Yuan, Mengxia; Luo, Yanfang; Ge, Anqi; Ge, Jinwen.
Afiliación
  • Yang K; Key Laboratory of Hunan Province for Integrated Traditional Chinese and Western Medicine on Prevention and Treatment of Cardio-Cerebral Diseases, School of Integrated Chinese and Western Medicine, Hunan University of Chinese Medicine, Changsha, China; Hunan Academy of Chinese Medicine, Changsha, Hun
  • Zeng L; Department of Rheumatology and Immunology, Nanjing Drum Tower Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Graduate School of Peking Union Medical College, Nanjing, China. Electronic address: zltab2016@hotmail.com.
  • Zeng J; The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan, China.
  • Deng Y; People's Hospital of Ningxiang City, Ningxiang, China.
  • Wang S; Key Laboratory of Hunan Province for Integrated Traditional Chinese and Western Medicine on Prevention and Treatment of Cardio-Cerebral Diseases, School of Integrated Chinese and Western Medicine, Hunan University of Chinese Medicine, Changsha, China.
  • Xu H; Key Laboratory of Hunan Province for Integrated Traditional Chinese and Western Medicine on Prevention and Treatment of Cardio-Cerebral Diseases, School of Integrated Chinese and Western Medicine, Hunan University of Chinese Medicine, Changsha, China.
  • He Q; People's Hospital of Ningxiang City, Ningxiang, China.
  • Yuan M; Joint Shantou International Eye Center of Shantou University and The Chinese University of Hong Kong, Shantou University Medical College, Shantou, China.
  • Luo Y; The Central Hospital of Shaoyang, Shaoyang, China.
  • Ge A; The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan, China.
  • Ge J; Key Laboratory of Hunan Province for Integrated Traditional Chinese and Western Medicine on Prevention and Treatment of Cardio-Cerebral Diseases, School of Integrated Chinese and Western Medicine, Hunan University of Chinese Medicine, Changsha, China; Hunan Academy of Chinese Medicine, Changsha, Hun
Ageing Res Rev ; 91: 102063, 2023 11.
Article en En | MEDLINE | ID: mdl-37673132
Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder of the central nervous system after Alzheimer's disease. The current understanding of PD focuses mainly on the loss of dopamine neurons in the substantia nigra region of the midbrain, which is attributed to factors such as oxidative stress, alpha-synuclein aggregation, neuroinflammation, and mitochondrial dysfunction. These factors together contribute to the PD phenotype. Recent studies on PD pathology have introduced a new form of cell death known as ferroptosis. Pathological changes closely linked with ferroptosis have been seen in the brain tissues of PD patients, including alterations in iron metabolism, lipid peroxidation, and increased levels of reactive oxygen species. Preclinical research has demonstrated the neuroprotective qualities of certain iron chelators, antioxidants, Fer-1, and conditioners in Parkinson's disease. Natural plant products have shown significant potential in balancing ferroptosis-related factors and adjusting their expression levels. Therefore, it is vital to understand the mechanisms by which natural plant products inhibit ferroptosis and relieve PD symptoms. This review provides a comprehensive look at ferroptosis, its role in PD pathology, and the mechanisms underlying the therapeutic effects of natural plant products focused on ferroptosis. The insights from this review can serve as useful references for future research on novel ferroptosis inhibitors and lead compounds for PD treatment.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Productos Biológicos / Enfermedades Neurodegenerativas / Ferroptosis Límite: Humans Idioma: En Revista: Ageing Res Rev Asunto de la revista: GERIATRIA Año: 2023 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Productos Biológicos / Enfermedades Neurodegenerativas / Ferroptosis Límite: Humans Idioma: En Revista: Ageing Res Rev Asunto de la revista: GERIATRIA Año: 2023 Tipo del documento: Article Pais de publicación: Reino Unido