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Aspirin for primary prevention in patients with high cardiovascular risk: insights from CORE-Thailand registry.
Wongcharoen, Wanwarang; Osataphan, Nichanan; Prasertwitayakij, Narawudt; Suwannasom, Pannipa; Suraamornkul, Swangjit; Wongtheptian, Wattana; Gunaparn, Siriluck; Sirikul, Wachiranun; Phrommintikul, Arintaya.
Afiliación
  • Wongcharoen W; Division of Cardiology, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand.
  • Osataphan N; Division of Cardiology, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand.
  • Prasertwitayakij N; Division of Cardiology, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand.
  • Suwannasom P; Division of Cardiology, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand.
  • Suraamornkul S; Faculty of Medicine Vajira Hospital, Navamindradhiraj University, Bangkok, Thailand.
  • Wongtheptian W; Division of Cardiology, Department of Internal Medicine, Chiang Rai Prachanukroh Hospital, Chiang Rai, Thailand.
  • Gunaparn S; Division of Cardiology, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand.
  • Sirikul W; Department of Community Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
  • Phrommintikul A; Division of Cardiology, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand. arintaya.p@cmu.ac.th.
Sci Rep ; 13(1): 14646, 2023 09 05.
Article en En | MEDLINE | ID: mdl-37670101
Aspirin may be considered for primary prevention in non-elderly patients with high cardiovascular risk. However, contemporary management aimed at aggressive cardiovascular risk factor control may alter benefit-risk ratio of aspirin. Therefore, we aimed to examine the effect of aspirin for primary prevention on the long-term MACEs in a large cohort registry. Cohort Of patients with high Risk for cardiovascular Events (CORE-Thailand) registry is a prospective, multicenter, observational, longitudinal study of Thai patients with high atherosclerotic risk. Patients with established atherosclerotic cardiovascular diseases were excluded. Among 4259 patients with multiple cardiovascular risk factors, 1945 (45.7%) patients used aspirin. After propensity score matching, there were 3228 patients remained in post-matching analysis. During the median follow-up period of 58.2 months, we demonstrated that aspirin use increased risk of long-term MACEs in pre-matching cohort (unadjusted HR 1.76, 95% CI 1.43-2.17, P < 0.001) and post-matching cohort (HR 1.66 (1.31-2.10), P < 0.001). In addition, patients taking aspirin had a higher risk of bleeding than non-aspirin users in pre-matching cohort (unadjusted HR 2.28, 95% CI 1.09-4.75, P = 0.028). We demonstrated that aspirin was associated with increased risk of long-term MACEs in patients with multiple cardiovascular risk factors. Due to the non-randomized design, our results should be interpreted with caution.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Cardiovasculares / Myristica / Aterosclerosis Tipo de estudio: Clinical_trials / Etiology_studies / Observational_studies / Risk_factors_studies Límite: Humans / Middle aged País/Región como asunto: Asia Idioma: En Revista: Sci Rep Año: 2023 Tipo del documento: Article País de afiliación: Tailandia Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Cardiovasculares / Myristica / Aterosclerosis Tipo de estudio: Clinical_trials / Etiology_studies / Observational_studies / Risk_factors_studies Límite: Humans / Middle aged País/Región como asunto: Asia Idioma: En Revista: Sci Rep Año: 2023 Tipo del documento: Article País de afiliación: Tailandia Pais de publicación: Reino Unido