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Axo-glial interactions between midbrain dopamine neurons and oligodendrocyte lineage cells in the anterior corpus callosum.
Caldwell, Megan; Ayo-Jibunoh, Vanessa; Mendoza, Josue Criollo; Brimblecombe, Katherine R; Reynolds, Lauren M; Zhu Jiang, Xin Yan; Alarcon, Colin; Fiore, Elizabeth; N Tomaio, Jacquelyn; Phillips, Greg R; Mingote, Susana; Flores, Cecilia; Casaccia, Patrizia; Liu, Jia; Cragg, Stephanie J; McCloskey, Dan P; Yetnikoff, Leora.
Afiliación
  • Caldwell M; CUNY Neuroscience Collaborative, The Graduate Center, City University of New York, 365 5Th Ave, New York, NY, 10016, USA.
  • Ayo-Jibunoh V; Department of Psychology, College of Staten Island, City University of New York, 2800 Victory Boulevard, Staten Island, NY, 10314, USA.
  • Mendoza JC; Department of Psychology, College of Staten Island, City University of New York, 2800 Victory Boulevard, Staten Island, NY, 10314, USA.
  • Brimblecombe KR; Department of Biology, College of Staten Island, City University of New York, 2800 Victory Boulevard, Staten Island, NY, 10314, USA.
  • Reynolds LM; Centre for Integrative Neuroscience, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, OX1 3PT, UK.
  • Zhu Jiang XY; Oxford Parkinson's Disease Centre, University of Oxford, Oxford, OX1 3PT, UK.
  • Alarcon C; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815, USA.
  • Fiore E; Plasticité du Cerveau, CNRS UMR8249, École Supérieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Paris, France.
  • N Tomaio J; Department of Biology, College of Staten Island, City University of New York, 2800 Victory Boulevard, Staten Island, NY, 10314, USA.
  • Phillips GR; Department of Psychology, College of Staten Island, City University of New York, 2800 Victory Boulevard, Staten Island, NY, 10314, USA.
  • Mingote S; Department of Psychology, College of Staten Island, City University of New York, 2800 Victory Boulevard, Staten Island, NY, 10314, USA.
  • Flores C; CUNY Neuroscience Collaborative, The Graduate Center, City University of New York, 365 5Th Ave, New York, NY, 10016, USA.
  • Casaccia P; Neuroscience Initiative, Advanced Science Research Center, Graduate Center of The City University of New York, New York, NY, USA.
  • Liu J; CUNY Neuroscience Collaborative, The Graduate Center, City University of New York, 365 5Th Ave, New York, NY, 10016, USA.
  • Cragg SJ; Department of Biology, College of Staten Island, City University of New York, 2800 Victory Boulevard, Staten Island, NY, 10314, USA.
  • McCloskey DP; Center for Developmental Neuroscience, College of Staten Island, City University of New York, 2800 Victory Boulevard, Staten Island, NY, 10314, USA.
  • Yetnikoff L; CUNY Neuroscience Collaborative, The Graduate Center, City University of New York, 365 5Th Ave, New York, NY, 10016, USA.
Brain Struct Funct ; 228(8): 1993-2006, 2023 Nov.
Article en En | MEDLINE | ID: mdl-37668732
Oligodendrocyte progenitor cells (OPCs) receive synaptic innervation from glutamatergic and GABAergic axons and can be dynamically regulated by neural activity, resulting in activity-dependent changes in patterns of axon myelination. However, it remains unclear to what extent other types of neurons may innervate OPCs. Here, we provide evidence implicating midbrain dopamine neurons in the innervation of oligodendrocyte lineage cells in the anterior corpus callosum and nearby white matter tracts of male and female adult mice. Dopaminergic axon terminals were identified in the corpus callosum of DAT-Cre mice after injection of an eYFP reporter virus into the midbrain. Furthermore, fast-scan cyclic voltammetry revealed monoaminergic transients in the anterior corpus callosum, consistent with the anatomical findings. Using RNAscope, we further demonstrate that ~ 40% of Olig2 + /Pdfgra + cells and ~ 20% of Olig2 + /Pdgfra- cells in the anterior corpus callosum express Drd1 and Drd2 transcripts. These results suggest that oligodendrocyte lineage cells may respond to dopamine released from midbrain dopamine axons, which could affect myelination. Together, this work broadens our understanding of neuron-glia interactions with important implications for myelin plasticity by identifying midbrain dopamine axons as a potential regulator of corpus callosal oligodendrocyte lineage cells.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cuerpo Calloso / Neuronas Dopaminérgicas Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Brain Struct Funct Asunto de la revista: CEREBRO Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cuerpo Calloso / Neuronas Dopaminérgicas Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Brain Struct Funct Asunto de la revista: CEREBRO Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Alemania