Stability of milrinone in 0.45% sodium chloride, 0.9% sodium chloride, or 5% dextrose injections.
Am J Hosp Pharm
; 43(9): 2218-20, 1986 Sep.
Article
en En
| MEDLINE
| ID: mdl-3766576
The stability of milrinone in 0.45% and 0.9% sodium chloride injections and in 5% dextrose injection in glass and plastic containers was studied. Admixtures containing milrinone 0.2 mg/mL were prepared in three 500-mL glass containers, three 500-mL polyethylpolypropyl copolymer plastic containers, and three 1-L flexible plastic containers of each solution. Milrinone content was determined by high-performance liquid chromatography at intervals during 72 hours of storage at room temperature; one sample of each solution and container type was protected from light. Duplicate assays of each sample were performed, and samples were observed for visual and pH changes. In all samples milrinone concentrations were more than 97% of the initial concentration. No changes in pH or appearance occurred. Milrinone at a concentration of 0.2 mg/mL is stable for 72 hours at room temperature in 0.45% and 0.9% sodium chloride injections and in 5% dextrose injection in glass or plastic containers.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Piridonas
Idioma:
En
Revista:
Am J Hosp Pharm
Año:
1986
Tipo del documento:
Article
Pais de publicación:
Estados Unidos