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Expression analysis of inhibitory B7 family members in Alzheimer's disease.
Sabaie, Hani; Tamimi, Parham; Gharesouran, Jalal; Salkhordeh, Zoha; Asadi, Mohammad Reza; Sharifi-Bonab, Mirmohsen; Shirvani-Farsani, Zeinab; Taheri, Mohammad; Sayad, Arezou; Rezazadeh, Maryam.
Afiliación
  • Sabaie H; Clinical Research Development Unit of Tabriz Valiasr Hospital, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Tamimi P; School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Gharesouran J; Department of Medical Genetics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Salkhordeh Z; Department of Medical Genetics, Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran.
  • Asadi MR; Clinical Research Development Unit of Tabriz Valiasr Hospital, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Sharifi-Bonab M; Clinical Research Development Unit of Tabriz Valiasr Hospital, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Shirvani-Farsani Z; Department of Cell and Molecular Biology, Faculty of Life Sciences and Technology, Shahid Beheshti University, Tehran, Iran.
  • Taheri M; Institute of Human Genetics, Jena University Hospital, Jena, Germany. rezazadehm@tbzmed.ac.ir.
  • Sayad A; Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. rezazadehm@tbzmed.ac.ir.
  • Rezazadeh M; Department of Medical Genetics, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. ar.sayad@yahoo.com.
Metab Brain Dis ; 38(8): 2563-2572, 2023 Dec.
Article en En | MEDLINE | ID: mdl-37665469
Alzheimer's disease (AD) is a global health problem due to its complexity, which frequently makes the development of treatment methods extremely difficult. Therefore, new methodologies are necessary to investigate the pathophysiology of AD and to treat AD. The interaction of immune modulation and neurodegeneration has added new dimensions in current knowledge of AD etiology and offers an attractive opportunity for the discovery of novel biomarkers and therapies. Using quantitative polymerase chain reaction, we compared the expression levels of inhibitory B7 family members (B7-1, B7-2, B7-H1, B7-DC, B7-H3, B7-H4, B7-H5, B7-H7, and ILDR2), as immune regulators, in the peripheral blood of late-onset AD (LOAD) patients (n = 50) and healthy individuals (n = 50). The levels of B7-2, B7-H4, ILDR2, and B7-DC expression were significantly higher in-patient blood samples than in control blood samples. Furthermore, we discovered a substantial positive correlation between all gene expression levels. In addition, the current study indicated that ILDR2, B7-H4, B7-2, and B7-DC might serve as diagnostic biomarkers to identify LOAD patients from healthy persons. The present work provides additional evidence for the significance of inhibitory B7 family members to the etiology of LOAD.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Alzheimer / Inhibidor 1 de la Activación de Células T con Dominio V-Set Límite: Humans Idioma: En Revista: Metab Brain Dis Asunto de la revista: CEREBRO / METABOLISMO Año: 2023 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Alzheimer / Inhibidor 1 de la Activación de Células T con Dominio V-Set Límite: Humans Idioma: En Revista: Metab Brain Dis Asunto de la revista: CEREBRO / METABOLISMO Año: 2023 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Estados Unidos